نتایج جستجو برای: cerebral vasospasm

تعداد نتایج: 186646  

Journal: :Journal of applied physiology 2005
Mitsuo Yamaguchi-Okada Shigeru Nishizawa Masayo Koide Yuichiro Nonaka

Because it has been argued that active myogenic tone prolongs cerebral vasospasm for >2 wk after subarachnoid hemorrhage (SAH), we attempted to identify the mechanism that plays the main role in sustaining the prolonged cerebral vasospasm. We especially focused on the roles of biomechanical and phenotypic changes in the cerebral arteries in the mechanisms of prolonged vasospasm after SAH. We us...

Journal: :Stroke 2002
Patrik Gabikian Richard E Clatterbuck Charles G Eberhart Betty M Tyler Travis S Tierney Rafael J Tamargo

BACKGROUND AND PURPOSE A reduction in the local availability of nitric oxide (NO) may play a role in the etiology of chronic cerebral vasospasm after subarachnoid hemorrhage (SAH). We investigated the toxicity and efficacy of a locally delivered NO donor from a controlled-release polymer in preventing experimental cerebral vasospasm in rats and rabbits, respectively. METHODS Diethylenetriamin...

Journal: :Stroke 2001
S Condette-Auliac S Bracard R Anxionnat E Schmitt J C Lacour M Braun J Meloneto A Cordebar L Yin L Picard

BACKGROUND AND PURPOSE Vasospasm secondary to subarachnoid hemorrhage (SAH) is responsible for severe ischemic complications. Although effective, angioplasty must be performed at a very early stage to produce any clinical recovery. Diagnostic investigations to assess arterial narrowing (transcranial Doppler, angiography) or cerebral perfusion (xenon CT, single-photon emission CT) do not provide...

2014
Chia-Mao Chang Yu-Feng Su Chih-Zen Chang Chia-Li Chung Yee-Jean Tsai Joon-Khim Loh Chih-Lung Lin

Cerebral vasospasm is the leading cause of mortality and morbidity in patients after aneurysmal subarachnoid hemorrhage (SAH). However, the mechanism and adequate treatment of vasospasm are still elusive. In the present study, we evaluate the effect and possible mechanism of progesterone on SAH-induced vasospasm in a two-hemorrhage rodent model of SAH. Progesterone (8 mg/kg) was subcutaneously ...

Journal: :Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2004
Changman Zhou Mitsuo Yamaguchi Gen Kusaka Claudio Schonholz Anil Nanda John H Zhang

Apoptosis in the endothelium of major cerebral arteries may play a role in the initiation and maintenance of cerebral vasospasm after subarachnoid hemorrhage (SAH). We tested the therapeutic effect of caspase inhibitors on endothelial apoptosis and on cerebral vasospasm in an established dog double-hemorrhage model. Thirty-one mongrel dogs were divided into five groups: control; SAH; SAH treate...

2010
Mark R Harrigan

Although hyperdynamic therapy is an accepted method of treatment of patients with symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage, it remains unproven in large scale trials and controlled studies. Furthermore, methods of hyperdynamic therapy and specific endpoints vary widely. A systematic review of clinical trials of the various techniques of hyperdynamic therapy and th...

2009
Mervyn D.I. Vergouwen Marinus Vermeulen

Background and Purpose—A recent meta-analysis investigating the efficacy of statin treatment in patients with aneurysmal subarachnoid hemorrhage reported a reduced incidence of vasospasm, delayed cerebral ischemia, and mortality in statin-treated patients. However, the meta-analysis was criticized for its methodology, and several retrospective studies found no beneficial effect. We present the ...

2016
Raimund Helbok Alexandra Zangerle Andreas Chemelli Ronny Beer Thomas Benke Rainer Ehling Marlene Fischer Martin Sojer Bettina Pfausler Claudius Thome Erich Schmutzhard

INTRODUCTION Vasospasm still is a major cause of morbidity after aneurysmal subarachnoid hemorrhage. The purpose of this report is to describe the successful management of severe refractory vasospasm with continuous intra-arterial nimodipine (IAN) treatment. CASE DESCRIPTION A 72-year old right handed woman was admitted with non-traumatic SAH WFNS grade 1. Cerebral computed tomography demonst...

Journal: :Stroke 1989
A Hino N Mizukawa H Tenjin Y Imahori S Taketomo I Yano H Nakahashi K Hirakawa

Positron emission tomography was performed using an oxygen-15 gas inhalation technique to measure regional cerebral blood flow, metabolic rate for oxygen, oxygen extraction fraction, and cerebral blood volume in 13 patients with subarachnoid hemorrhage during the period of delayed vasospasm after surgery as well as in 10 volunteers as controls. Compared with the controls, the patients showed de...

Journal: :Stroke 1994
T Otsuji S Endo Y Hirashima M Nishijima A Takaku

BACKGROUND AND PURPOSE There are many experimental models for studies of cerebral vasospasm. However, no ideal model has been established thus far to comparatively reproduce the ischemic state of the brain that may occur in patients after subarachnoid hemorrhage. METHODS In the present study, we attempted to induce severe vasospasm in rabbits by using an oxyhemoglobin-rich blood product prepa...

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