Purpose: The study was initiated to obtain epidemiologic data and information on anatomic distribution, clinical features and treatment results in patients with primary supratentorial anaplastic astrocytoma and glioblastoma multiform. Patients and Methods: Between January 2000 and January 2006, 113 primary high grade astrocytoma patients were eligible to evaluate clinical features. Radiotherapy...

Astrocytoma is the most common type of primary malignant brain tumor, with pretty lowly 5-year survival rate in patients. Although extended surgical removal of the tumor and postoperative chemotherapy/radiotherapy executed, still there is large recurrence rate, mainly because diffuse glioma tumor cells ubiquitously infiltrate into normal parenchyma. So it becomes a priority to hunt novel molecu...

The purpose of this work is to remind doctors practical medicine about the importance differential diagnosis with cancers in general pediatric practice and increase vigilance clinicians regarding similarity manifestations oncology infectious diseases on example specific clinical cases. We conducted an empirical, descriptive study 4 cases children. selected them among 21 patients who were diagno...

background: high-grade astrocytoma (grade 4) or glioblastoma multiforme (gbm) are deadly brain tumors. new therapies attempt to increase lifetime and quality of life in patients with malignant astrocytoma. o6-methylguanine-dna methyltransferase (mgmt) enzyme expression may be effective in prognosis and response to treatment of these patients. the aim of this study was assessment of mgmt enzyme ...

We have shown previously that, in astrocytoma cells, synemin is present at the leading edge, an unusual localization for an intermediate filament (IF) protein. Here, we report that synemin down-regulation with specific small hairpin RNAs (shRNAs) sharply decreased the migration of astrocytoma cells. The presence of synemin at the leading edge also correlated with a high migratory potential, as ...

BACKGROUND Gliomas are highly malignant with a poor prognosis. Studies have reported that DNA repair genes influence risk for glioma, but its relationship with prognosis is unclear. In this study, we want to explore the relationship between DNA repair genes (XRCC3, XRCC4 and XRCC5) and prognosis of astrocytoma in the Chinese Han population. MATERIALS AND METHODS 160 astrocytoma cases were rec...

Astrocytoma, the most common brain tumor in humans, is usually malignant and virtually incurable. Two types of malignant astrocytomas can be distinguished histopathologically: anaplastic astrocytoma and glioblastoma multiforme. Studies using DNA markers that detect restriction fragment length polymorphisms have shown that loci on chromosomes 10 and 17p are lost frequently in tumor DNA from mali...

BACKGROUND/AIMS The mitotic kinesin superfamily protein KIF14 is essential for cytokinesis and chromosome segregation, and increased KIF14 expression is related to a variety of human cancers. However, the role of KIF14 in the development and malignant progression of astrocytomas and the underlying mechanisms remain unclear. The present study examined the relation between KIF14 and the pathogene...

Cerebral radionecrosis is a significant side effect in radiotherapy for brain cancer. The purpose of this study is to calculate the relative biological effectiveness (RBE) of carbon-ion beams on brain cells and to show RBE-weighted dose distributions for cerebral radionecrosis speculation in a carbon-ion treatment planning system. The RBE value of the radionecrosis for the carbon-ion beam is ca...