Three independent studies of tight glucose control were recently stopped prematurely due to an excess mortality in the intensive treatment arm. This commentary briefly discusses the potential mechanisms and reminds the potential benefits of physiological stress hyperglycemia.

The software industry is facing a great challenge. While systems get more complex and distributed across the world, users are becoming more dependent on their availability. As systems increase in size and complexity so does the risk that some part will fail. Unfortunately, it has proven hard to tackle faults in distributed systems without a rigorous approach. Therefore, it is crucial that the s...

The problem of reconstruction of band-limited signals from discrete and noisy data is studied. The reconstruction schemes employing cardinal expansions are proposed and their asymptotical properties are examined. In particular, the conditions for the convergence of the mean integrated squared errors are found and the rate of convergence is evaluated. The main difference between the proposed rec...

The extraction of a Minimal Unsatisfiable Core (MUC) in a Constraint Satisfaction Problem (CSP) aims to identify a subset of constraints that make a CSP instance unsatisfiable. Recent work has addressed the identification of a Minimal Set of Unsatisfiable Tuples (MUST) in order to restore the CSP satisfiability with respect to that MUC. A two-step algorithm has been proposed: first, a MUC is id...

Titin, a giant protein spanning half the sarcomere, is responsible for passive and restoring forces in cardiac myofilaments during sarcomere elongation and compression, respectively. In addition, titin has been implicated in the length-dependent activation that occurs in the stretched sarcomere, during the transition from diastole to systole. The purpose of this study was to investigate the rol...

We propose a novel microscopy image restoration algorithm capable of co-restoring Phase Contrast and Differential Interference Contrast (DIC) microscopy images captured on the same cell dish simultaneously. Cells with different phase retardation and DIC gradient signals are restored into a single image without the halo artifact from phase contrast or pseudo 3D shadow-casting effect from DIC. Th...