ABSTRACT First Person is a series of interviews with the first authors selection papers published in Journal Cell Science, helping researchers promote themselves alongside their papers. Madison Rogers author on ‘ PDGFR dimer-specific activation, trafficking and downstream signaling dynamics’, JCS. PhD student lab Dr Katherine A. Fantauzzo at University Colorado Anschutz Medical Campus, Aurora, ...

Immunotherapy has emerged as a specific treatment, guided by oncologic targets, that given the false impression (to oncologists and hematologists) it had no adverse effects, including cardiovascular complications. Chimeric antigen receptor (CAR) T-cell therapy certainly benefited patients; in contrast, reports of effects have emerged. In this paper, we conducted narrative review conceptual aspe...

Maintenance of skin homeostasis requires meticulous regulation the induction, repression and degradation key signaling factors governing progenitor cell terminal differentiation programs. Deregulation these pathways is a hallmark barrier disruption often manifested in disease. Timed controlled orchestration networks involves ubiquitin ubiquitin-like proteins, as abnormal targeted or post-transl...

introduction: stroke is one of the most important reasons of death. hence, trials to prevent or lessen the complications originated by stroke are a goal of public health worldwide. the ischemia-reperfusion causes hypoxia, hypoglycemia and incomplete repel of metabolic waste products and leads to accumulation of free radicals triggering neuronal death. the a1 adenosine receptoras an endogenous l...

Bispecific antibodies (BsAbs) have been developed, with one antigen-binding site coordinated against the CD3 receptor (which activates cytotoxic T lymphocytes) and other specific antigens found on cancer cells (CD19, CD20, CD33, CD123, HER2, epithelial cell adhesion molecule [EpCAM], BCMA, CEA, others) [1].

objective(s): t-cell acute lymphoblastic leukemia (t-all) is an aggressive hematologic malignant tumor. administration of chemical compounds influencing apoptosis and t cell development has been discussed as promising novel therapeutic strategies. valproic acid (vpa) as a recently emerged anti-neoplastic histone deacetylase (hdac) inhibitor and pioglitazone (pgz) as a high-affinity peroxisome p...

Severe acute respiratory syndrome coronavirus has a great role in causing illness humans and the most important relationship of its spike proteins with host ACE-2 receptors. After entry into human body, viral S protein receptor-binding domain binds to receptor. Two modes explained this paper an shedding. The shedding induces process cells by binding SARS-CoV-2 proteins. residues arginine lysine...

CD8⁺cytotoxic T cells, CD4⁺ helper and regulatory cells interact differently with cancer. CD8⁺ cytotoxic recognize the antigens presented by cancer kill in various ways. recruit other immune promote them to destroy cells. On hand, suppress cell proliferation response of both This suppressive mechanism often leads progression These cell-cancer interactions can render conventional treatments inef...