cell replacement therapy has provided the basis for future clinical applications to treat central nervous system injuries fallowing by car accidents. induced functional neurons are an option for replacing the lost neurons. the ability to monitor changes in membrane potential is a useful tool for studying neuronal function, but there are only limited options available at present. here, investiga...

overdose of acetaminophen causes severe hepatic necrosis in humans and experimental animals. studies on its hepatotoxicity remain a very active area since some of current data are still uncertain. in this study, freshly isolated rat hepatocytes were used to determine the effects of garlic extract and its component, allicin on the acetaminophen-induced cell cytotoxicity and to compare with the e...

introduction:  electroporation  is  a  technique  for  increasing  the  permeability  of  the  cell  membrane  to  otherwise  non-permeate  molecules  due  to  an  external  electric  field.  this  permeability  enhancement  is  detectable if the induced transmembrane voltage becomes greater than a critical value which depends on the  pulse  strength  threshold.  in  this  study,  the  variabil...

Thioridazine (TZ) is used mainly in the treatment of schizophrenia. However, hepatotoxicity as a life-threatening adverse effect is associated with its clinical use. In this context, we examined the cytotoxic mechanisms of TZ on freshly isolated rat hepatocytes to better understanding of the pathogenesis of TZ-induced hepatotoxicity. Hepatocytes were prepared by the method of collagenase enzyme...

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a particular strain responsible for the disease 2019 (COVID-19), accounting more than 3.1 million deaths worldwide. Several health-related strategies have been successfully developed to contain rapidly-spreading virus across globe, toward reduction of both burden and infection rates. Particularly, attention has focuse...

hedera helix  is widely used to treat bronchial asthma for many years. however, effects of this herb on lung histopathology is still far from clear. we aimed to determine the effect of oral administration of hedera helix on lung histopathology in a murine model of chronic asthma. balb/c  mice  were  divided  into  four  groups;   i  (placebo),  ii  (hedera  helix), iii (dexamethasone) and iv (c...

Despite the availability and prosperity of chemotherapeutic agents, multidrug resistance (MDR) remains paramount obstacle in antitumor chemotherapy. Here, a natural killer (NK) cell-biomimetic nanoparticle (DMLN) is developed to overcome MDR by promoting entry doxorubicin (DOX) into tumor cells via cascade catalysis. DMLN synthesized compounding NK cell membrane with hollow MnO2 nanoparticles l...

Introduction:  Electroporation  is  a  technique  for  increasing  the  permeability  of  the  cell  membrane  to  otherwise  non-permeate  molecules  due  to  an  external  electric  field.  This  permeability  enhancement  is  detectable if the induced transmembrane voltage becomes greater than a critical value which depends on the  pulse  strength  threshold.  In  this  study,  the  variabil...

This paper presents the modeling and simulation of a proton exchange membrane fuel cell (PEMFC) generation system for off-grid and on-grid operation and configuration. A fuel cell DG system consists of a fuel cell power plant, a DC/DC converter and a DC/AC inverter. The dynamic model for fuel cell array and its power electronic interfacing are presented also a multi-input single output (MISO) D...

introduction: we have recently reported the presence of two potassium currents with 598 and 368 ps conductance in the rough endoplasmic reticulum (rer) membrane. the 598 ps channel was voltage dependent and atp sensitive. however, the 368 ps channel was rarely observed and its identity remained obscure. since cationic channels in intracellular organelles such as mitochondria and rer play import...