Waldenstroms Macroglobulinaemia (WM) is a rare B-cell lymphoma representing ~2% of all haematological malignancies. While most neurological complications WM are secondary to the overproduction Immunoglobulin M (IgM), Bing-Neel Syndrome (BNS) an extremely direct Central Nervous System (CNS) infiltration by malignant Lymphoplasmocytic Lymphoma (LPL) cells. Limited information on BNS exists in lit...

Angioimmunoblastic T-cell lymphoma (AITL) is a rare and aggressive form of peripheral (PTCL). It can present with signs symptoms that have broad differentials, including fevers, night sweats, skin rashes. In this case report, we an interesting young male Nigerian descent recently treated malaria who presented such picture was complicated, due to inconclusive excisional biopsy for lymphoma. He l...

BACKGROUND Gene expression profiling has successfully identified the prognostic significance of the host response in lymphomas. The aggressive T-cell/histiocyte-rich large B-cell lymphoma and the indolent nodular lymphocyte-predominant Hodgkin's lymphoma are both characterized by a paucity of tumor cells embedded in an overwhelming background. The tumor cells of both lymphomas share several cha...

Clonal chromosome abnormalities were found in 89 (97%) of 92 patients with non-Hodgkin's malignant lymphoma including immunologically determined 34 B- and 25 T-lymphomas; only 3 of 19 T-lymphoma patients examined had serum adult T-cell leukemia/lymphoma-associated antigen antibody. Association of 8q24 translocations with small non-cleaved cell (P less than 0.01) and that of t(14;18) (q32;q21) w...

Cutaneous T-cell lymphoma describes a heterogeneous group of neoplasms of skin homing T cells that vary considerably in clinical presentation, histologic appearance, immunophenotype, and prognosis. This paper addresses the cutaneous T-cell lymphoma in Asians with respect to clinical-epidemiologic and histopathological features. Compared with Western countries, Asia usually has higher rates of c...

BACKGROUND B-cell lymphoma comprises the majority of non-Hodgkin lymphomas worldwide. Hematopoietic cell transplantation (HCT) is used for patients with high-risk, relapsed, or refractory B-cell lymphoma. METHODS The current medical literature and the results of recently published trials were reviewed to provide an update on the most common indications for HCT in B-cell lymphoma. RESULTS Au...

Introduction: Mature T and NK-cell lymphomas represent a heterogeneous group of lymphoid disorders (29 subtypes according to the 2016 WHO classification) arising from mature cells post-thymic origin with different morphological characteristics, phenotypes, clinical presentation. Following success Cell Project (TCP), which allowed analysis more than 1,500 cases peripheral T-Cell (PTCLs) collecte...


 CADTH recommends that Minjuvi, in combination with lenalidomide, not be reimbursed by public drug plans for the treatment of relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) otherwise specified, including DLBCL arising from low grade lymphoma, who are eligible autologous stem cell transplant (ASCT).
 The clinical evidence reviewed was strong enough to show whether ...

Diffuse large B-cell lymphoma, not otherwise specified, is the most common type of non-Hodgkin lymphoma worldwide, accounting for 30-40% all lymphomas. It represents a collection morphologically, genetically and clinically different diseases. Therefore, it can be subdivided into morphological variants, phenotypic subtypes, molecular or genetic categories. More recently, diffuse has witnessed ad...