The current study evaluated the general toxicity, antioxidant, antimicrobial, and cytotoxic activity of extracts obtained from the rhizomes of Eremostachys azerbaijanica (Labiatae) as well as analyzed the potent extracts using GC-MS. Extracts of E. azerbaijanica in n-hexane, dichloromethane (DCM) and methanol (MeOH) were prepared using a Soxhlet apparatus. The antioxidant activity of the extrac...

the current study evaluated the general toxicity, antioxidant, antimicrobial, and cytotoxic activity of extracts obtained from the rhizomes of eremostachys azerbaijanica (labiatae) as well as analyzed the potent extracts using gc-ms. extracts of e. azerbaijanica in n-hexane, dichloromethane (dcm) and methanol (meoh) were prepared using a soxhlet apparatus. the antioxidant activity of the extrac...

Factors controlling the last stages of clathrin-coated vesicle formation were investigated using an assay allowing direct measurement of the detachment of these vesicles from the plasma membrane. Plasma membranes from cultured cells surface-labelled with 125I-alpha2-macroglobulin (a ligand that preferentially associates with clathrin-coated pits) were isolated by sonication of cells attached to...

Introduction: Salvia hispanica L. is an annual herbaceous plant commonly known as "Chia", native of southern Mexico and northern Guatemala. The aim this study isolation, identification secondary metabolites evaluation biological activities ethyl acetate fraction aerial parts. Methods: Air dried powdered parts was extracted by maceration fractionated using light petroleum, dichloromethane solven...

BACKGROUND miRNAs are critical post-transcriptional regulators of gene expression and key mediators of tumourigenesis. miR-501-5p is newly identified to be involved in the tumor progression, but its biological role and mechanism remain largely unknown. This study is aimed to study the role of miR-501-5p in the progression of gastric cancer. METHODS Real-time PCR analysis was used to determine...

Background and objectives: Ferula gummosa Boiss. (Umbelliferae) is a popular medicinal plant, which is known mostly for therapeutic uses of its oleo-gum-resin (Barijeh in Persian). In the present study, the essential oil of F. gummosa roots was investigated for its phytochemical constituents, antioxidant activity and toxicity potential. Method...

Human oral squamous cell carcinomas (hSCCs) are the most common head and neck cancers now presenting with more aggressive biological clinical features due to smoking alcohol together widespread viremia. Transforming growth factor-β (TGF-β) proteins powerful morphogens that induce rapid substantial induction of endochondral bone formation but in primates only.

Background and Hypothesis: It has been demonstrated that the protective degradative process of autophagy is defective in context human T1D. Additionally, a type I interferon-inducible transcriptional signature detected blood cells children genetically at risk for T1D prior to appearance autoantibodies. Preliminary data demonstrate can be stimulated by IFN-α β-cells non-diabetic mice, but this r...

BACKGROUND Adipocyte volume (fat accumulation) and cell number (adipogenesis) is increased in obese individuals. Our objective was the identification of dietary constituents with inhibitory effects on triglyceride formation during adipogenesis. Therefore an in vitro adipose cell assay in murine C3H10 T1/2 cells was developed, which enabled rapid quantification of intracellular fat droplet accum...

UNLABELLED SMAD4 has been suggested to inhibit the activity of the WNT/β-catenin signaling pathway in cancer. However, the mechanism by which SMAD4 antagonizes WNT/β-catenin signaling in cancer remains largely unknown. Aurora A kinase (AURKA), which is frequently overexpressed in cancer, increases the transcriptional activity of β-catenin/T-cell factor (TCF) complex by stabilizing β-catenin thr...