photodynamic therapy (pdt) using 5-aminolevulinic acid (5-ala)-induced protoporphyrin ix (ppix) has been considered as a new method for treating neoplasms. however, ala-pdt is suboptimal for thick tumors. searching for new approaches, we investigated the effect of adding differentiation therapy (dt) with vitamin e succinate (ves) to pdt in human prostate ln-cap-fgc10 cancer cells in vitro . the...

background gelatin and chitosan are known as biodegradable and biocompatible biopolymers.these biopolymers have recently receivedincreasingly more attention for tissueengineering.the aim of this study was to evaluate the toxicity effects of gelatin-chitosan film on bone marrow stromal cell(bmscs) culture in rat.                                                  material & methods: first, gelatin...

background: several studies have demonstrated the immunosuppresive effects of mes-enchymal stem cells (mscs) in allogeneic or mitogenic interactions. cell-cell contact inhibition and secretion of suppressive soluble factors have been suggested in this re-gard. objective: to investigate if adipose derived mscs could inhibit jurkat lym-phoblastic leukemia t cell proliferation during coculture. me...

background: in addition to the well-defined histological criteria for squamous cell carcinoma (scc) and basal cell carcinoma (bcc), immunohistochemical techniques can be used in difficult cases for their differentiation. as differential diagnosis between trichoepithelioma (te) and bcc is sometimes difficult for the clinician and the pathologist, cd10 may be a useful marker for definite diagnosi...

Bone tissue engineering has been one of the most promising areas of research, providing a potential clinical application to cure bone defects. Recently, various stem cells, including embryonic stem cells (ESCs), bone marrow-derived mesenchymal stem cells (BM-MSCs), umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs), adipose tissue-derived stem cells (ADSCs), muscle-derived stem cell...

background: in the field of cellular therapy, the impact of confluence degree to harvest or differentiate bmmscs and the effect of cell-to-cell contact remains controversial. therefore, the effect of confluence on bmmscs properties was studied and confluence-associated osteogenic differentiation efficiency was identified. materials and methods: the impact of confluences at 20, 50, 70, 80 and 10...

background: adult stem cells (asc) are undifferentiated cells found throughout the body. these cells are promising tools for cell replacement therapy in neurodegenerative disease. adipose tissue is the most abundant and accessible source of asc. this study was conducted to evaluate effect of selegiline on differentiation of adipose-derived stem cells (adsc) into functional neuron-like cells (nl...

background: while articular chondrocytes are among those appropriate candidates for cartilage regeneration, the cell dedifferentiation during monolayer culture has limited their application. several investigations have indicated the usefulness of alginate, but the topic of proliferation and differentiation of chondrocytes in alginate culture has still remained controversial. methods: rat articu...

objective(s): umbilical cord blood is a good source of the mesenchymal stem cells that can be banked, expanded and used in regenerative medicine.  the objective of this study was to test whether amniotic membrane extract, as a rich source of growth factors such as basic-fibroblast growth factor, can promote the proliferation potential of the umbilical cord mesenchymal stem cells. materials and ...