Introduction: Cesarean surgical site infection (SSI) occurs in 3% to 17% of patients who undergo cesarean delivery. SSIs increase postcesarean maternal morbidity and health costs and cause longer hospital stays. Therefore, we designed a study to assess the effects of normal saline and cefazolin irrigation on the incidence of SSIs. Methods: In this study, 200 participants were divided into 3 gr...

introduction: methicillin-resistant staphylococcus aureus (mrsa) can cause serious and life-threatening hospital- and community-acquired infections. colonized and infected patients represent the most important reservoir of mrsa in health care facilities. therefore, in this study, mrsa isolates collected from shohada hospital in tabriz were evaluated for the frequency of meca gene and their anti...

BACKGROUND In patients with symptomatic cholelithiasis, laparoscopic cholecystectomy (LC) is the standard method of treatment. Laparoscopic cholecystectomy has a low rate of postoperative infections probably owing to smaller wounds and minimal tissue damage compared with the open procedure. OBJECTIVES This study assessed the effect of cefazolin prophylaxis on postoperative infection in patien...

The extent of physico-chemical changes induced by irradiation of cefazolin sodium was investigated. The methods used were potency determination, impurity profile, colour measurements and pH measurements. The potency of irradiated samples at 25 kGy was 4+/-2% lower than that of the non irradiated ones. The total amount of related substances increased from 0.72+/-0.01% in the non irradiated sampl...

The in vitro activities of five cephalosporin antibiotics against 121 strains of salmonellae were compared. Cefamandole and cefaclor were more potent than cefazolin, and these three drugs were more active than cephalothin and cephalexin.

TO THE EDITOR—Urinary tract infections (UTIs) remain a common indication for antibiotic therapy in children [1]. They are frequently managed in the outpatient setting where availability of susceptibility results may be delayed, making selection of appropriate initial therapy important. We sought to evaluate susceptibility patterns of antibiotic agents used to treat UTIs in children by developin...

Worldwide, cefazolin is one of the most commonly used antibiotics, as revealed in a recent article this Journal, 1 Thamlikitkul V. Rattanaumpawan P. Sirijatuphat R. Wangchinda W. Integrated one-day surveillance antimicrobial use, consumption, resistance, healthcare-associated infection, and resistance burden among hospitalized patients Thailand. J Infect. Jul 2020; 81: 98-106 Abstract Full Text...

We compared the intraocular pharmacokinetics of cefazolin with those of cefamandole, a recently marketed cephalosporin with enhanced activity against gram-negative bacilli. Following subconjunctival injection of 12.5 mg into infected eyes (S. aureus endophthalmitis) of pigmented rabbits, both drugs reached peak concentrations greater than 100 microgram/gm in cornea, sclera, and choroid-retina. ...

An experimental Klebsiella pneumoniae pneumonia in rats was used to study the effect of protein binding of cefoxitin and cefazolin on their therapeutic activity. Both cephalosporins were similar with respect to their antimicrobial activity against the K. pneumoniae in vitro, but they differed in their degree of protein binding, being 34% for cefoxitin and 89 to 93% for cefazolin in uninfected r...