نتایج جستجو برای: cdc42

تعداد نتایج: 3729  

Journal: :Infection and immunity 1998
G Ben-Ami V Ozeri E Hanski F Hofmann K Aktories K M Hahn G M Bokoch I Rosenshine

Enteropathogenic Escherichia coli (EPEC) induces formation of actin pedestals in infected host cells. Agents that inhibit the activity of Rho, Rac, and Cdc42, including Clostridium difficile toxin B (ToxB), compactin, and dominant negative Rho, Rac, and Cdc42, did not inhibit formation of actin pedestals. In contrast, treatment of HeLa cells with ToxB inhibited EPEC invasion. Thus, Rho, Rac, an...

Journal: :Molecular biology of the cell 1997
R T Müller U Honnert J Reinhard M Bähler

myr 5 is an unconventional myosin (class IX) from rat that contains a Rho-family GTPase-activating protein (GAP) domain. Herein we addressed the specificity of the myr 5 GAP activity, the molecular mechanism by which GAPs activate GTP hydrolysis, the consequences of myr 5 overexpression in living cells, and its subcellular localization. The myr 5 GAP activity exhibits a high specificity for Rho...

Journal: :Biochemical Society transactions 2013
Maitreyi Das Fulvia Verde

Cell polarization is fundamental to many cellular processes, including cell differentiation, cell motility and cell fate determination. A key regulatory enzyme in the control of cell morphogenesis is the conserved Rho GTPase Cdc42, which breaks symmetry via self-amplifying positive-feedback mechanisms. Additional mechanisms of control, including competition between different sites of polarized ...

Journal: :Molecular and cellular biology 2000
S Sarner R Kozma S Ahmed L Lim

Ras and Rho family GTPases have been ascribed important roles in signalling pathways determining cellular morphology and growth. Here we investigated the roles of the GTPases Ras, Cdc42, Rac1, and Rho and that of phosphatidylinositol 3-kinase (PI 3-kinase) in the pathway leading from serum starvation to neurite outgrowth in N1E-115 neuroblastoma cells. Serum-starved cells grown on a laminin mat...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2014
Jena Fediuk Anurag S Sikarwar Nora Nolette Shyamala Dakshinamurti

In hypoxic pulmonary arterial (PA) myocytes, challenge with thromboxane mimetic U46619 induces marked actin polymerization and contraction, phenotypic features of persistent pulmonary hypertension of the newborn (PPHN). Rho GTPases regulate the actin cytoskeleton. We previously reported that U46619-induced actin polymerization in hypoxic PA myocytes occurs independently of the RhoA pathway and ...

2012
Shannon P. Fortin Matthew J. Ennis Cassie A. Schumacher Cassandra R. Zylstra-Diegel Bart O. Williams Julianna T.D. Ross Jeffrey A. Winkles Joseph C. Loftus Marc H. Symons Nhan L. Tran

Malignant glioblastomas are characterized by their ability to infiltrate into normal brain.We previously reported that binding of the multifunctional cytokine TNF-like weak inducer of apoptosis (TWEAK) to its receptor fibroblast growth factor–inducible 14 (Fn14) induces glioblastoma cell invasion via Rac1 activation. Here, we show that Cdc42 plays an essential role in Fn14-mediated activation o...

Journal: :Journal of cell science 2002
Kayla J Bayless George E Davis

Here we show a requirement for the Cdc42 and Rac1 GTPases in endothelial cell (EC) morphogenesis in three-dimensional extracellular matrices. Cdc42 and Rac1 specifically regulate EC intracellular vacuole and lumen formation in both collagen and fibrin matrices. Clostridium difficile toxin B (which blocks all three Rho GTPases) completely inhibited the ability of ECs to form both vacuoles and lu...

Journal: :The Journal of Cell Biology 1998
William E. Allen Daniel Zicha Anne J. Ridley Gareth E. Jones

Three members of the Rho family, Cdc42, Rac, and Rho are known to regulate the organization of actin-based cytoskeletal structures. In Bac1.2F5 macrophages, we have shown that Rho regulates cell contraction, whereas Rac and Cdc42 regulate the formation of lamellipodia and filopodia, respectively. We have now tested the roles of Cdc42, Rac, and Rho in colony stimulating factor-1 (CSF-1)-induced ...

2017
Claire de Groot Amalia Floriou-Servou Yuan-Chen Tsai Simon Früh Manuela Kohler Georgia Parkin Cornelia Schwerdel Giovanna Bosshard Kai Kaila Jean-Marc Fritschy Shiva K Tyagarajan

In developing brain neuronal migration, dendrite outgrowth and dendritic spine outgrowth are controlled by Cdc42, a small GTPase of the Rho family, and its activators. Cdc42 function in promoting actin polymerization is crucial for glutamatergic synapse regulation. Here, we focus on GABAergic synapse-specific activator of Cdc42, collybistin (CB) and examine functional differences between its sp...

Journal: :Cancer research 2014
Ryotaro Sakamori Shiyan Yu Xiao Zhang Andrew Hoffman Jiaxin Sun Soumyashree Das Pavan Vedula Guangxun Li Jiang Fu Francesca Walker Chung S Yang Zheng Yi Wei Hsu Da-Hai Yu Lanlan Shen Alexis J Rodriguez Makoto M Taketo Edward M Bonder Michael P Verzi Nan Gao

Mutations in the APC or β-catenin genes are well-established initiators of colorectal cancer, yet modifiers that facilitate the survival and progression of nascent tumor cells are not well defined. Using genetic and pharmacologic approaches in mouse colorectal cancer and human colorectal cancer xenograft models, we show that incipient intestinal tumor cells activate CDC42, an APC-interacting sm...

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