Divalent ions of the first series transition elements and Hg were introduced into a cadmium hydroxyapatite Cd5 (P04) 30H by replacing a part of Cd2+, and the effects on the crystal growths and the structural changes were studied. Cd2+ can be exchanged with Mn2+ up to about 30 mol %, with N¡Z+or Hg2+ up to about 10 mol %, and with a little amount of Fe2+ or Cu2+. It was found that Cd5 (PO.)sOH f...

We describe 69 patients in whom small clonal B-cell populations were detected incidentally in blood and bone marrow samples by flow cytometric studies. In 20 patients (29%), non-Hodgkin lymphoma (NHL) subsequently was diagnosed 0 to 40 months (median, 0.1 month) from initial flow cytometric studies. In 49 patients (71%), there was no evidence of NHL after 0.5 to 72 months (median, 16 months). P...

B-cell chronic lymphocytic leukemia (B-CLL), the most common leukemia in the Western world, occurs in two forms, aggressive (showing for the most part high ZAP-70 expression and unmutated IgH V(H)) and indolent (showing low ZAP-70 expression and mutated IgH V(H)). We found that miR-29a is up-regulated in indolent human B-CLL as compared with aggressive B-CLL and normal CD19(+) B cells. To study...

Background: Adenocarcinoma of the prostate is an invasive carcinoma, a neoplasm epithelial cells with secretory cell differentiation. Histomorphology glandular. The are sheets or single neoplasia, basal not seen in this carcinoma. Tumor-Infiltrating Lymphocytes (TILs) lymphocytes that migrate to tumor peritumoral cells. In malignancy, T lymphocyte infiltration can be found, indicating immune re...

Induction of T-cell activation requires multiple signals provided by cell surface receptor interactions and/or cytokines. T-cell stimulation via the T-cell receptor/CD3 complex provides an important initial activation event which, when combined with the proper costimulatory signals, re sults in an activated effector T cell. In this report, we have investigated the effectiveness of epithelial gl...

We report 4 cases of splenic marginal zone lymphoma (SMZL) with peripheral CD5 positive, B-cell lymphocyto-sis. This unusual immunophenotypic discordance raises dilemmas in the diagnostic approach of these patients. In addition, this association may be related to a more aggressive clinical course, as 3 out of 4 of our patients died from progressive disease. Splenic marginal zone lymphoma (SMZL)...

Non-Hodgkin's lymphomas are divided into B- and T-cell neoplasms. The existence and the clinical relevance of lymphomas derived from the third lymphocyte lineage, ie, natural killer (NK) cells are still controversial. NK cells are lymphocytes that mediate cytotoxicity without prior sensitization. NK cells also have phenotypic and genotypic characteristics: they express the NK-related antigen CD...

Preeclampsia is a devastating pregnancy-associated disorder affecting 5% to 8% of pregnant women worldwide. It emerges as an autoimmune-driven disease, and, among others, the autoantibodies against angiotensin type 1 receptor II have been proposed to account for preeclampsia symptoms. Despite much attention focused on describing autoantibodies associated with preeclampsia, there is no clue conc...

Recently the minor B cell subpopulation that expresses the CD5 (Leu-1) antigen has been implicated as a source of IgM autoantibodies. Chronic lymphocytic leukemia (CLL), the most common leukemia in humans, represents a malignancy of small B lymphocytes that also express the CD5 antigen. However, little is known concerning the antibody variable region genes (V genes) that are used by these malig...