Background: Regulatory T cells have been suggested to have a protective role against acute rejection in allograft recipients. However, there is little information available about their contribution to chronic rejection process. The role of transforming growth factor-beta 1 (TGF- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. Objectives: To eva...

Background: Dendritic cells (DC) are a key regulator of the immune response, and interferon- beta (IFN-β) is considered an immunomodulatory molecule for DC. Objective: The purpose of this study was to evaluate the ability of IFN-β treated DC to induce cytokine secretion by CD4+ T cells. Methods: Dendritic cells were generated from blood monocytes with granulocyte-monocyte colony-stimulating fac...

Infertile marriage is a complex socio-economic problem; the frequency of infertility in Ukraine 17-20%, which prompts further study its mechanisms, including immune ones, order to develop appropriate methods correction. Purpose - characterize phenotypic features T-cells and their subpopulation T-helpers (CD3+CD4+) with expression intracellular cytokines women history at different stages pregnan...

Sezary syndrome (SS) is the leukemic variant of CD4+ cutaneous T-cell lymphoma. Mogamulizumab an FDA-approved monoclonal antibody targeting surface CCR4 on SS cells. We’ve previously described highly expressed biomarker genes and altered cytokine gene expression that favors a Th2-immune phenotype. Here we evaluated mogamulizumab’s efficacy in reducing malignant T-cells, decreasing expression, m...

This was a cross sectional study designed to evaluate the cluster of differentiation 4(CD4) count and hematological indices in HIV serodiscordant partners Jos, Nigeria. A total 20 Serodiscordant couples (40 patients) non controls) aged between 18 49 years were included study. Each participant provided 5ml venous blood sample that collected into EDTA containers for analysis CD4 indices. The foll...

Background: Candida albicans is one of the most important opportunistic pathogens that suppress immunologic mechanisms of the host. It is speculated that structural and secretory proteins of C. albicans have immunomodulatory effects in cancer. Objective: To evaluate the effects of C. albicans structural and secreted proteins on intratumoral CD4/CD8 ratio as well as the survival rate in BALB/c t...