Chronic pelvic inflammatory disease (PID) in women remains a problem due to the importance of medical consequences. The study receptor apparatus neutrophilic granulocytes (NG) involved anti-infective protection diseases various etiologies seems be relevant. Aim: clarify features variants quantitative and phenotypic changes subsets NG CD11b + CD64 - CD32 CD16 , immunocompromised during exacerbat...

BACKGROUND With more than 600,000 deaths from malaria, mainly of children under five years old and caused by infection with Plasmodium falciparum, comes an urgent need for an effective anti-malaria vaccine. Limited details on the mechanisms of protective immunity are a barrier to vaccine development. Antibodies play an important role in immunity to malaria and monocytes are key effectors in ant...

Obese AT (adipose tissue) exhibits increased macrophage number. Pro-inflammatory CD16+ peripheral monocyte numbers are also reported to increase with obesity. The present study was undertaken to simultaneously investigate obesity-associated changes in CD16+ monocytes and ATMs (AT macrophages). In addition, a pilot randomized placebo controlled trial using the PPAR (peroxisome-proliferator-activ...

background: infertility is an increasing medical and social problem. in vitro fertilization (ivf) has become a common and accessible treatment for a wide variety of indications that have variable outcomes. natural killer (nk) cells have been identified as relevant immunological factors involved in reproductive success or failure. objective: the aim of this study was to compare the percentage of...

doi:10.1160/TH13-05-0367 Thromb Haemost 2013; 110: 1080–1082 Dear Sirs, The zinc finger transcription factor Krüppel-like factor 4 (KLF4) plays an important role in the regulation of cellular functions, including proliferation, differentiation or activation (1). Circulating monocytes, which give rise to tissue-resident macrophages, are essential cellular mediators of atherosclerosis (2). Recent...

The putative factors that couple the signal transduction from surface receptors to the activation of cytokine synthesis in natural killer (NK) cells have not been elucidated. We report here that the nuclear factor of activated T cells (NFATp), a cyclosporin A (CsA)-sensitive factor that regulates the transcription of several cytokines, mediates CD16-induced activation of cytokine genes in human...

Introduction. The actual task of modern adoptive cancer immunotherapy is the selection optimal composition cytokines for ex vivo stimulation immunocompetent cells subsequent administration to oncological patients. purpose study was compare effect interleukin (IL) 2, 7, 15 and their combinations on proliferation natural killer in breast (BC) patients vitro. Materials methods. research conducted ...

It was demonstrated that cetuximab-induced tumor regression is based on the effects exerted by immune cells included mainly in the innate immune response. Therefore, the focus of this study was to explore the alterations in the percentages of CD16+, and/or CD56+ lymphocytes, which are comprised of NK cells, and minority of CD56+CD3+ cells, in patients with metastatic colorectal cancer before or...