PURPOSE Selective immunoglobulin A deficiency is the most common primary immunodeficiency disorder that is strongly overrepresented among patients with celiac disease (CD). IgG antibodies against tissue transglutaminase (tTG) and deamidated gliadin peptides (DGP) serve as serological markers for CD in IgA deficient individuals, although the diagnostic value remains uncertain. The aim of this st...

OBJECTIVE Previous research suggested that structural and functional abnormalities within the amygdala and orbitofrontal cortex contribute to the pathophysiology of Conduct Disorder (CD). Here, we investigated whether the integrity of the white-matter pathways connecting these regions is abnormal and thus may represent a putative neurobiological marker for CD. METHODS Diffusion Tensor Imaging...

Introduction Cartilage-derived retinoic acid-sensitive protein (CDRAP) is a 11-kDa protein and isolated from bovine articular chondrocytes and human melanoma cell lines (melanoma inhibitory activity or MIA). In normal tissue, it is expressed specifically in cartilage cells, but in tumors it has been shown to be expressed in melanoma, chondrosarcoma, and breast cancer to date. CD-RAP/MIA is expr...

OBJECTIVE Recent work indicates that the gut microflora is altered in patients with coeliac disease (CD). Faecal short-chain fatty acids (SCFAs) are produced by the gut microflora. We have previously reported a high SCFA output in children with symptomatic and asymptomatic CD at presentation, as well as in CD children on a gluten-free diet (GFD) for less than 1 year, indicating deviant gut micr...

DNA/RNA Description DNA contains 27.322 kb composed of 20 coding exons. Exons 1-2 encode the 5' untranslated region and the signal peptide, exons 3-7 the five EGF domains, exons 8-13 the extracellular stalk, exons 14-18 the seven-span transmembrane (TM7) domains and exons 19-20 the intracellular part and the 3' untranslated region. Transcription 3247 bp mRNA transcribed in telomeric to centrome...

The lumen-to-cell transport, cellular accumulation, and toxicity of ionic cadmium (Cd) and cadmium-cysteine conjugate (Cys-S-Cd-S-Cys) were studied in isolated perfused S2 segments of the proximal tubule of the rabbit kidney. All perfusion solutions were HEPES buffered and contained H-L-glucose which functioned as a volume and leak marker along with 250 nM FD & C Green dye as a vital dye. When ...

Urinary cadmium (U-Cd) is commonly interpreted in epidemiological studies to measure cadmium accumulated in the kidney, and is thus used as a marker of long-term exposure. This concept is based primarily on occupational cohorts exposed to high Cd levels, and its generaliza tion to populations chronically exposed to lower environmental Cd levels—primarily through tobacco and foods grown on conta...