The present study was designed to investigate the synergistic hepatoprotective effect of Silymarin in combination with standardised extracts of Picrorrhiza kurroa, Phyllanthus amarus, Tephrosia purpurea, Asparagus racemosus plants against experimental hepatotoxicity induced by administration of Paracetamol (3g/kg; p.o) and Carbontetrachloride (1ml/kg; s.c) in wistar rats. Paracetamol and CCl4 i...

The unique characters of camel's milk make it used extensively in the field of medicine as anti-microbial, anti-diabetic and hepatoprotective agent. The lack of studies demonstrating the protective effect of camel's milk against hepatotoxic compound was the main reason beyond the conduction of the current experiment which aimed to investigate the protective effects of camel's milk against carbo...

Abstract Background In spite of the huge advances in recent medicine, there is no effective drug that completely protects liver from toxic materials. This study was conducted to investigate hepatoprotective effect arctigenin burdock ( Arctium lappa ) against carbon tetrachloride (CCl 4 )-induced injury. Results Arctigenin pre-administration reduced hepatotoxicity markers significantly as compar...

The present study determines the efficacy of N-acetyl cysteine (NAC) on marker enzymes, lipid peroxidation and antioxidants in carbon tetrachloride induced hepatotoxicity in rats. Carbon tetrachloride (CCl4) (3 mL/kg/week) administered subcutaneously to albino Wistar rats for a period of three months significantly increased the activities of marker enzymes in plasma such as aspartate transamina...

Gallic acid (3,4,5-trihydroxybenzoic acid, GA), a natural phenolic acid has been reported as a strong antioxidant. Therefore the present study was designed to evaluate the effects of GA and dodecyl gallate (DGA) against acute and chronic carbon tetrachloride (CCl4)-induced hepatotoxicity. For acute model, rats were orally treated with GA and DGA for 7 d prior to CCl4 by intraperitoneally (i.p.)...