objective: the present study was conducted to investigate the hepatoprotective activity of hydro-ethanolic fruit extract of rosa canina (r. canina) against carbon tetrachloride (ccl4)-induced hepatotoxicity in rats. methods: male wistar albino rats were randomly divided into six groups of 8 animals of each, including control, toxic (ccl4), r. canina 250, 500, and 750 mg/kg + ccl4 and r. canina ...

The liver is an essential organ in the body for detoxification drugs and toxic substances. present study was designed to investigate hepatoprotective effects of L-Cysteine, Ursodeoxycholic acid (Ursoflor), Silymarin against carbon tetrachloride-induced injury rats. Twenty adult male rats were used this work; they randomly divided into five groups (4 rats/group). first group served as control re...

Background: Various investigations have established that carbon tetrachloride (CCl4), a clear, colourless, volatile, heavy and nonflammable liquid, causes generation of free radicals in many tissues such as testis. a wide range of side effects such as reproductive toxicity has been observed following the administration of this liquid in experimental animals. Numerous studies have shown that amo...

The methanol extract of Bauhinia racemosa Lam. (Caesalpiniaceae) stem bark was investigated for the antioxidant and hepatoprotective effects in Wistar albino rats. Different groups of animals were administered with paracetamol (500 mg/kg, (p.o.) once in a day for 7 days) and carbon tetrachloride (CCl4) (30 % CCl4, 1 ml/kg b.wt. in liquid paraffin 3 doses (i.p.) at 72 h interval). The methanol e...

The present study was investigated to evaluate the protective and therapeutic role of Moringa oleifera leaf extract (MOLE) against CCL4-induced toxicity in rats . Male Albino rats of eleven groups (eight animals each) were used in this study : negative control ; control of olive oil ; positive control received CCL4 in olive oil for 12 weeks ; groups 4-7 received CCl4 in olive oil + MOLE at dose...

Epstein-Barr virus (EBV)-encoded nuclear antigen, EBNA2, expressed in EBV-infected B lymphocytes is critical for lymphoblastoid cell growth. Microarray profiling and cytokine array screening revealed that EBNA2 is associated with upregulation of the chemokines CCL3 and CCL4 in lymphoma cells. Depletion or inactivation of CCL3 or CCL4 sensitized DLBCL cells to doxorubicin. Our results indicate t...

The aim of the present study was to investigate the hepatoprotective effect of green tea extract (GTE) against the hepatic fibrosis induced by carbon tetrachloride (CCl4), ethanol, and dual exposure to CCl4 plus ethanol in rats. In particular, an investigation of the three-dimensional architecture was conducted using scanning electron microscopy. Various techniques revealed that hepatic fibrosi...

BACKGROUND In vitro bioassays are important in the evaluation of plants with possible hepatoprotective effects. The aims of this study were to evaluate the pretreatment of HepG2 cells with hepatoprotective agents against the damage induced by carbon tetrachloride (CCl4) and paracetamol (APAP). METHODS Antioxidative activity was measured using an assay to measure 2,2-diphenyl-1-picrylhydrazyl ...

BACKGROUND AND OBJECTIVES The present study aimed to evaluate the protective and curative effects of the 15 KD protein isolated from the seeds of Peganum harmala L. against carbon tetrachloride (CCl4) induced oxidative stress in rats. MATERIALS AND METHODS In the protective study, animals were pretreated intraperitoneally with 15 KD isolated protein at doses of 4 and 8 mg/kg body weight as we...