نتایج جستجو برای: caspase3 gene
تعداد نتایج: 1141611 فیلتر نتایج به سال:
GADD45α is a stress-induced gene activated by a variety of stress stimuli, including ultraviolet and ionizing radiation, and involved in cell cycle regulation, apoptosis, maintenance, genomic stability, DNA repair and immune response. However, the effects and regulatory mechanism of GADD45α on proliferation, apoptosis and DNA damage repair of hepatocytes in liver regeneration remains unclear. I...
BACKGROUND Recent studies have indicated that the nuclear RNA-binding protein RBM5 has the ability to modulate apoptosis and suppress tumor growth. The aim of this study is to investigate the expression of RBM5 in human prostate cancer and its mechanism of tumor suppression. METHODS The expression of RBM5 protein in cancerous prostatic tissues and normal tissues was examined by IHC. PC-3 cell...
BACKGROUND Metastasis-associated in colon cancer 1 (MACC1) is demonstrated to be up-regulated in several types of cancer, and can serve as biomarker for cancer invasion and metastasis. To investigate the relations between MACC1 and biological processes of ovarian cancer, MACC1 specific small hairpin RNA (shRNA) expression plasmids were used to investigate the effects of MACC1 inhibition on ovar...
PURPOSE MicroRNAs (miRNAs) are endogenously expressed, small noncoding RNAs that inhibit gene expression by binding to target mRNAs. Recent studies have revealed that miRNAs function as tumor suppressors or oncogenes. In the present study, we investigated the role of miRNA-34b/c in uveal melanoma. METHODS Real-time reverse transcriptase polymerase chain reaction (RT-PCR) was performed to dete...
The peripheral circadian oscillator plays an essential role in synchronizing local physiology to operate in a circadian manner via regulation of the expression of clock-controlled genes. The present study aimed to evaluate the circadian rhythms of clock genes and clock-controlled genes expressed in the rat uterus endometrial stromal cells (UESCs) during the stage of implantation by a DNA microa...
Podocytes are terminally differentiated glomerular epithelial cells. Podocyte loss has been found in many renal diseases. Cdk5 is a cyclin-dependent protein kinase which is predominantly regulated by p35. To study the role of Cdk5/p35 in podocyte survival, we first applied western blotting (WB) analysis to confirm the time-course expression of Cdk5 and p35 during kidney development and in cultu...
OBJECTIVE This study was performed to compare the efficiency of slow freezing and vitrification based on survival, development to blastocysts, and cell numbers of blastocysts. Changes in embryonic gene expression in fresh and frozen-thawed embryos were also examined. METHODS Eight-cell stage embryos were collected from superovulated female BDF1 mice. The collected embryos were randomly divide...
ریحان(ocimum basilicum l.) از گیاهان دارویی تیره نعناع و سرشار از ترکیبات فنیل پروپانوئیدی است. در این تحقیق به منظور مطالعه تأثیر متیل جاسمونات بر بیان ژن های چاویکول-o-متیل ترنسفراز(cvomt) و سینامات چهار هیدروکسیلاز (c4h) (ژن های کلیدی دخیل در بیوسنتز فنیل پروپانوئیدها) و آنزیم های آنتی اکسیدانت آسکوربات پراکسیداز و گایاکول پراکسیداز در گیاه ریحان رقم کشکنی لولو، آزمایشی بر پایه طرح کاملاً تصا...
Natural antioxidants (NAs) are promising substances, which established as potent therapeutic agents. However, the anticancer potential of many them is not completely known. In this research, effect three natural including geraniol (Ge), citronellol (Cit), and quercetin (Qu), their combination by estimating cytotoxicity on Hela cells at doses from 15.625 to 1000 µg/mL was investigated. Moreover,...
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