Serum concentrations of beta-alanine and l-histidine are compared in five normal adults after ingestion of the dipeptide carnosine (beta-alanyl-l-histidine) and after equivalent amounts of the constituent free amino acids. The results indicate that absorption is significantly more rapid after the ingestion of the amino acids than after the dipeptide. The use of the test in a case of Hartnup dis...

Carnosine was first isolated from beef muscle extract by Gulewitsch and Amiradsibi (10) in 1900, and has subsequently been shown to have a wide-spread occurrence in mammalian skeletal muscle. The investigations of Gulewitsch (8, 9), Baumann and Ingvaldsen (3), and Barger and Tutin (2) proved that carnosine is /3-alanyl-Lhistidine. Anserine was isolated from an extract of goose flesh by Ackerman...

A relaxing system requiring phosphocreatine as the relaxant may be restored to glycerinated psoas fibers by incubation in a reaction mixture containing pyridoxal phosphate, calcium, carnosine, magnesium, ATP, and sodium maleate at pH 6.5. The capacity to relax, once established, persists after elution in buffer of the diffusible fraction of the reactants. The relaxation by phosphocrestine is re...

Background Early research with beta-alanine (b-ALA) supplementation has shown increases in muscle carnosine as well as improvements in body composition, exercise performance and blood lactate levels. Creatine monohydrate supplementation has been extensively researched for its effects on anaerobic exercise performance. Recently, studies have examined the combined effects b-ALA and creatine suppl...

The complete removal of glioblastoma brain tumours is impossible to achieve by surgery alone due the complex finger-like tentacle structure tumour cells and their migration away from bulk at time surgery; furthermore, despite aggressive chemotherapy radiotherapy treatments following surgery, continue grow, leading death patients within 15 months after diagnosis. naturally occurring carnosine di...

Type 2 diabetes is characterised by failure to control glucose homeostasis, with numerous diabetic complications attributable the resulting exposure of cells and tissues chronic elevated concentrations fatty acids. This, in part, results from formation advanced glycation lipidation end-products that are able modify protein, lipid, or DNA structure, disrupt normal cellular function. Herein we us...

Carnosine, homocarnosine and anserine have been proposed to act as antioxidants in vivo. Our studies show that all three compounds are good scavengers of the hydroxyl radical (.OH) but that none of them can react with superoxide radical, hydrogen peroxide or hypochlorous acid at biologically significant rates. None of them can bind iron ions in ways that interfere with 'site-specific' iron-depe...

It has been documented that telomere-associated cellular senescence may contribute to certain age-related disorders, and telomere length (TL) may be an informative biomarker of healthy aging. Hormone-brain-aging behavior-modulated telomere dynamics and changes in telomerase activity are consistent elements of cellular alterations associated with changes in proliferative state, and these process...