Accepted 25 September 1996 Traditionally, the endothelium had been regarded simply as a passive barrier lining blood vessels. However, in 1980, Furchgott and Zawadski elegantly demonstrated that the endothelium was important in vascular relaxation by releasing an endothelium-derived relaxing factor (EDRF). 1 The precise identity ofEDRF remained elusive until 1987 when Palmer et al showed that E...

Objectives: To determine the community based prevalence of rheumatic heart disease (RHD) in the rural population of the district of Rahim Yaar Khan in Pakistan. Subjects and methods: A representative sample of the rural population of Rahim Yaar Khan district was selected. RHD was screened for by physical examination and the diagnosis was confirmed with echocardiographic Doppler studies. Sociode...

Peripheral artery disease (PAD), which consists of partial or complete obstruction of the arteries in the lower limbs, is one of the most common manifestations of atherosclerosis, affecting 27 million individuals in Europe and North America.1 Its main symptomatic expression, intermittent claudication, was first described by the French veterinarian Bouley2 in a horse affected by progressive limp...

Advances in genomic technologies have provided researchers with an unprecedented opportunity to identify genes that may contribute to the development of coronary heart disease. The power of these technologies lies in their ability to survey the entire genome in a nonbiased fashion to find genes and gene variants associated with coronary heart disease. This article reviews different genomic appr...

DEAR EDITOR, We read with great pleasure the manuscript by Ashrafi et al. published in a recent issue of the International Journal of Preventive Medicine. Their case highlights a very interesting association between celiac disease and pericardial manifestations. However, authors have not discussed the underlying mechanism for its causal association and treatment considerations for refractory ca...

Artificial intelligence has had an impact on a variety of fields, including medicine and, most importantly, cardiovascular diseases. Indeed, early diagnosis many disorders is serious medical issue. In this article, we will compare various machine learning algorithms in order to select the optimal one for diagnosing people who might suffer from heart disease based clinical data patients. The eff...

Cardiovascular disease is the leading cause of mortality and mobility in the Western developed world. Enormous efforts from biological scientists have significantly increased our knowledge of the atherosclerotic process. Yet, the clinical task of diagnosing and treating cardiovascular disease remains challenging. For example, we do not know how to predict heart attack and prevent the loss of li...

Erectile dysfunction (ED) is defined as the inability to achieve or maintain a penile erection for satisfactory sexual performance and it is estimated that >300 million men will suffer from this condition in 2025. ED is recognized as a harbinger of cardiovascular disease. Endothelial dysfunction and macrovascular atherosclerotic disease together represent the probable pathophysiological link be...

normal 0 false false false en-us x-none ar-sa background: cardiovascular diseases, cardiovascular risk factors, and mortality due to these situations are more frequently encountered in schizophrenic patients when compared with the general population. the mean platelet volume (mpv) is a surrogate biomarker of the platelet activity and an useful prognostic test in cardiometabolic diseases. the ai...