Objective: Atherosclerosis is a chronic inflammatorycondition associatedwith the production of oxidative species. The phenoliccompound, resveratrol, seems to have cardioprotective activities preventing the oxidation of low-density lipoproteins. In this study we investigated the effect of resveratrol on prevention of induced atheromatosis, through the morphological study of the segment of aortic...

Cardioprotective activity of dexrazoxane (ICRF-187), the only clinically approved drug against anthracycline-induced cardiotoxicity, has traditionally been attributed to its iron-chelating metabolite. However, recent experimental evidence suggested that inhibition and/or depletion topoisomerase II? (TOP2B) by could be cardioprotective. Hence, we evaluated a series analogues and found their card...

The purpose of this study was to determine the cardioprotective effects of the repetitive pretreatment of acupuncture in rats with myocardial ischemia and reperfusion (MIR). Experimental MIR was produced by ligating and reperfusing the left anterior descending coronary artery in the rats. The elevated ST segments of electrocardiogram (ECG), cardiac arrhythmias, and ratio of infarct size/risk zo...

CLASSICAL ISCHEMIC PRECONDITIONING (IPC) occurs when single or multiple brief periods of coronary artery occlusion interspersed with brief periods of reperfusion precede a prolonged ischemic insult (3). IPC has been shown to result in a marked reduction of myocardial infarct size in all species studied and has been shown by some investigators to reduce myocardial stunning or the incidence of ca...

There is a close association between hyperglycemia and increased risk of mortality after acute myocardial infarction (AMI). However, whether acute hyperglycemia exacerbates myocardial ischemia/reperfusion (MI/R) injury remains unclear. We observed the effects of acute hyperglycemia on MI/R injury and on the cardioprotective effect of glucose-insulin-potassium (GIK). Male rats were subjected to ...

Ginsenoside Rb2 is one of the major active components of Panax ginseng. There is little research about cardioprotective effect of ginsenoside Rb2. The aim of this study was to explore the cardioprotective effects of ginsenoside Rb2 on animal model of myocardial ischemia/reperfusion (MI/R) injury in vivo and H2O2-induced stress in H9c2 cells in vitro. Pretreatment with ginsenoside Rb2 (10 and 20...

Premenopausal women with chest pain syndrome may have nonatherosclerotic coronary arteries with abnormal coronary flow. Estrogens have cardioprotective effect improving coronary vasodilatation. This case report discusses the consequences of leuprolide use by decreasing estrogen levels which led to acute myocardial infarction.

BACKGROUND Patients with diabetes and ischemic heart disease (IHD) are at high risk for adverse cardiac outcomes. Clinical practice guidelines recommend multiple cardioprotective medications to reduce recurrent events. We evaluated the association between cardioprotective medication adherence and mortality among patients with diabetes and IHD. METHODS In a retrospective cohort study of 3,998 ...