نتایج جستجو برای: cardiomyocyte differentiation

تعداد نتایج: 231576  

Journal: :American journal of physiology. Heart and circulatory physiology 2011
Hidekazu Ishida Shigetoyo Kogaki Jun Narita Hiroaki Ichimori Nobutoshi Nawa Yoko Okada Kunihiko Takahashi Keiichi Ozono

LEOPARD syndrome (LS) is an autosomal dominant inherited multisystemic disorder. Most cases involve mutations in the PTPN11 gene, which encodes the protein tyrosine phosphatase Src homology 2-containing protein phosphatase 2 (SHP2). LS frequently causes severe hypertrophic cardiomyopathy (HCM), even from the fetal period. However, the molecular pathogenesis has not been clearly elucidated. Here...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016
Jiabao Liu Peng Wu Hao Wang Yunle Wang Yingqiang Du Weili Cheng Zhihui Xu Ningtian Zhou Liansheng Wang Zhijian Yang

BACKGROUND/AIMS The discovery of c-kit+ cardiac stem cells (CSCs) provided us with new therapeutic targets to repair the damaged heart. However, the precise mechanisms regulating CSC proliferation and differentiation in the aged heart remained elusive. Necroptosis, a type of regulated cell death, has recently been shown to occur following myocardial infarction (MI); however, its effect on c-kit...

Journal: :American journal of physiology. Heart and circulatory physiology 2009
Shunsuke Takei Hinako Ichikawa Kohei Johkura Akimi Mogi Heesung No Susumu Yoshie Daihachiro Tomotsune Katsunori Sasaki

Cardiomyocytes derived from human embryonic stem (ES) cells are a potential source for cell-based therapy for heart diseases. We studied the effect of bone morphogenetic protein (BMP)-4 in the presence of fetal bovine serum (FBS) on cardiac induction from human H1 ES cells during embryoid body (EB) development. Suspension culture for 4 days with 20% FBS produced the best results for the differe...

2012
S Sa KE McCloskey

The generation of cardiomyocytes from human embryonic stem cells (hESC) enables a variety of potential therapeutic and diagnostic applications. However, progress is challenged by the low efficiency of cardiomyocyte differentiation. Recently, Kattman et al., 2011 showed that individual hESC lines required proper balance of the Activin A and BMP4 signaling for efficient cardiac differentiation, p...

2018
Chang-Hwan Yoon Tae-Won Kim Seok-Jin Koh Young-Eun Choi Jin Hur Yoo-Wook Kwon Hyun-Jai Cho Hyo-Soo Kim

Pluripotent stem cell (PSC) variations can cause significant differences in the efficiency of cardiac differentiation. This process is unpredictable, as there is not an adequate indicator at the undifferentiated stage of the PSCs. We compared global gene expression profiles of two PSCs showing significant differences in cardiac differentiation potential. We identified 12 up-regulated genes rela...

2015
Ivan Batalov Adam W Feinberg

Human pluripotent stem cells (PSCs) are a promising cell source for cardiac tissue engineering and cell-based therapies for heart repair because they can be expanded in vitro and differentiated into most cardiovascular cell types, including cardiomyocytes. During embryonic heart development, this differentiation occurs under the influence of internal and external stimuli that guide cells to go ...

Journal: :Circulation research 2002
Allen M Samarel

Congestive heart failure (CHF) is a syndrome affecting nearly 5 million Americans with 550 000 new cases diagnosed annually. Despite recent advances in pharmacological therapy, the enormity of the clinical problem has stimulated cardiovascular scientists to test a variety of new and provocative hypotheses that may ultimately prove useful in CHF prevention and treatment. One such novel approach ...

2014
Cheryl D. Waring Carla Vicinanza Angela Papalamprou Andrew J. Smith Saranya Purushothaman David F. Goldspink Bernardo Nadal-Ginard Daniele Torella Georgina M. Ellison

AIMS It is a dogma of cardiovascular pathophysiology that the increased cardiac mass in response to increased workload is produced by the hypertrophy of the pre-existing myocytes. The role, if any, of adult-resident endogenous cardiac stem/progenitor cells (eCSCs) and new cardiomyocyte formation in physiological cardiac remodelling remains unexplored. METHODS AND RESULTS In response to regula...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Xiaojun Lian Cheston Hsiao Gisela Wilson Kexian Zhu Laurie B Hazeltine Samira M Azarin Kunil K Raval Jianhua Zhang Timothy J Kamp Sean P Palecek

Human pluripotent stem cells (hPSCs) offer the potential to generate large numbers of functional cardiomyocytes from clonal and patient-specific cell sources. Here we show that temporal modulation of Wnt signaling is both essential and sufficient for efficient cardiac induction in hPSCs under defined, growth factor-free conditions. shRNA knockdown of β-catenin during the initial stage of hPSC d...

Journal: :Cell 1997
Silvia Arber John J Hunter John Ross Minoru Hongo Gilles Sansig Jacques Borg Jean-Claude Perriard Kenneth R Chien Pico Caroni

MLP is a LIM-only protein of terminally differentiated striated muscle cells, where it accumulates at actin-based structures involved in cytoarchitecture organization. To assess its role in muscle differentiation, we disrupted the MLP gene in mice. MLP (-/-) mice developed dilated cardiomyopathy with hypertrophy and heart failure after birth. Ultrastructural analysis revealed dramatic disruptio...

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