We measured diffusing capacities for carbon monoxide (DLCO) and nitric oxide, lung volume, and cardiac output by a rebreathing technique at two alveolar O2 tensions (PAO2) at rest and exercise. Membrane diffusing capacity for CO (DMCO) and VC were estimated from DLCO by the Roughton-Forster (RF) method and also from simultaneous lung diffusing capacity for NO and DLCO measured at one O2 tension...

ocular involvement is seen in approximately 25% of patients with sarcoidosis. uveitis is the most common ocular manifestation, but sarcoidosis may involve any part of the eye. orbital manifestations of sarcoidosis are uncommon with few series in the literature. a 65-year-old woman presented with redness of the right eye and painless, unilateral eyelid swelling. orbital scanning revealed mass in...

important problem. While autopsy findings suggest that up to 25% of patients with sarcoidosis (1) may have myocardial granulomas, only about 5% (2) of American patients with sarcoidosis manifest symptomatic cardiac disease. Cardiac involvement may result in heart block, wall motion abnormalities, cardiomyopathy, and malignant arrhythmias, all of which may adversely impact quality of life and su...

Cardiac MR imaging is an effective method for noninvasive imaging of the heart. The technology has been limited in the past because of imaging difficulties associated with cardiac motion. In recent years, however, cardiac MR imaging has broadened its spectrum of applications in cardiovascular disease with impressive advances in spatial and temporal resolution and increased imaging speeds. This ...

Non tropical, non hypereosinophilic endo myocardial fibrosis has been reported in literature and is a rare entity.  Cardiac Sarcoidosis manifesting as non-tropical, non hypereosinophilic endomyocardial fibrosis is unknown, though it classically affects the left ventricle and is not associated with specific risk factors. We describe an atypical presentation of sarcoidosis as non-tropical non hyp...

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Sarcoidosis is a multisystemic inflammatory disease, which accounts for substantial morbimortality. Cardiac involvement portends worse prognosis. A major limitation in the evaluation cardiac sarcoidosis that no gold standard clinical diagnostic criteria exists. magnetic resonance (CMR) may be indicated patients with s...

A 54-year-old man with clinically and pathologically diagnosed cutaneous, ocular and pulmonary sarcoidosis was referred to the Cardiology Department for a prolonged PR interval and intermittent advanced atrioventricular block (Picture 1A and B). Echocardiography, gallium-67 scintigraphy and cardiac magnetic resonance imaging revealed no evidence of cardiac sarcoid involvement. F-fluoro-2deoxygl...

Background The presence of myocardial late gadolinium enhancement (LGE) in patients with sarcoidosis is a powerful predictor of major adverse events (MAE: death, ventricular tachycardia, or appropriate ICD therapy). In this study, we aim to determine if the burden of LGE, left ventricular (LV) and right ventricular (RV) end-diastolic and end-systolic volume index (EDVi & ESVi) and ejection frac...