Identifying a bona fide population of cardiac stem cells (CSCs) is a critical step for developing cell-based therapies for heart failure patients. Previously, cardiac c-kit(+) cells were reported to be CSCs with a potential to become myocardial, endothelial and smooth muscle cells in vitro and after cardiac injury. Here we provide further insights into the nature of cardiac c-kit(+) cells. By t...

1 Cardiac catheterization has transformed the management of pediatric cardiac disease, as the indications for pediatric catheterization are broad and far-reaching.1–3 Cardiac catheterization, however, is not without risk. In pediatric patients, the rate of complications ranges from 7.8% to 16.2%.1,5–9 The most common complication is vascular injury, which accounts for nearly one third of all co...

A case of mitral incompetence and multiple ventricular septal defects following a non-penetrating chest injury is described. Cardiac injury was detected by electrocardiogram and by the appearance of a heart murmur in the second week after trauma. Superimposition of bacterial endocarditis seven years later caused cardiac decompensation and necessitated successful surgical treatment. Previous rep...

conclusions: normothermia and hemodynamic stability are the most important factors which help to reduce fetal loss during open heart surgery in pregnancy. the fetus has an auto-regulation which comes into play when the mother is experiencing shock. objectives: the aim of this study was to report our experience with urgent cardiopulmonary bypass carried out in early pregnancy and to analyze fact...

Aetna considers remote ischemic conditioning experimental and investigational for the treatment of aneurysmal subarachnoid hemorrhage, myocardial infarction, primary graft dysfunction following lung transplantation, spinal cord injury, traumatic brain injury, and other indications (e.g., for cardiac, cognitive, pulmonary and renal protection during cardiac surgery, endovascular aneurysm repair,...

RATIONALE A major goal for the treatment of heart tissue damaged by cardiac injury is to develop strategies for restoring healthy heart muscle through the regeneration and repair of damaged myocardium. We recently demonstrated that administration of a specific combination of microRNAs (miR combo) into the infarcted myocardium leads to direct in vivo reprogramming of noncardiac myocytes to cardi...

Soluble guanylate cyclase (sGC) has been suggested as a therapeutic target for cardiac ischemia-reperfusion (IR) injury. Until now, the molecular mechanism of BAY 60-2770, a sGC activator, in cardiac IR injury has not been assessed. To identify the cardioprotective effects of BAY 60-2770 in IR-injured rat hearts, IR injury was established by occlusion of LAD for 40 min and reperfusion for 7 day...

The widespread use of cardiac catheterization has revealed certain dangers inherent in the procedure when the catheter is advanced beyond the tricuspid valve. Ventricular and other ectopic rhythms are a well recognized risk, but less is known about the effect of damage to the endocardium produced by the catheter in man (Zimdahl, 1951). This paper presents in detail a case that terminated fatall...

Nonreceptor tyrosine kinases have an increasingly appreciated role in cardiac injury and protection. To investigate novel tasks for members of the Tec family of nonreceptor tyrosine kinases in cardiac phenotype, we examined the behavior of the Tec isoform in myocardial ischemic injury. Ischemia-reperfusion, but not cardiac protective agents, induced altered intracellular localization of Tec, hi...