Myocardial fibrosis is a common pathological feature of various terminal cardiovascular diseases. Progressive the basis for development and progression many cardiac arrhythmias heart failure. There are no effective reversal drugs myocardial due to lack understanding molecular mechanisms. Noncoding RNAs, class RNAs that do not function in coding proteins, have been found be intimately involved l...

Background Hypertrophic cardiomyopathy (HCM) is characterised by left ventricular hypertrophy, myofibre disarray as well as interstitial and replacement fibrosis. These characteristics are likely the underlying cause of reduced ventricular compliance and cardiac arrhythmias which subsequently impact on quality of life and outcome. Cardiac magnetic resonance (CMR) based late gadolinium imaging (...

Background Myocardial fibrosis is a hallmark of hypertrophic cardiomyopathy (HCM) and may contribute to arrhythmias and heart failure. Sarcomere mutations appear to induce profibrotic changes before left ventricular hypertrophy (LVH) develops. Measuring T1 relaxation times with contrast cardiac magnetic resonance (CMR) allows robust quantification of the cardiac extracellular volume (ECV) and n...

Objectives: To elucidate the role of KLF15 on cardiac fibroblast in the dynamic angiogenesis in pressureoverload cardiac remodeling. Methods: Aortic banding was performed in rats to induce pressure-overload and cardiac hypertrophy. Part of the animals has their aorta constriction removed 3 or 6 weeks after the banding surgery. Cardiac function by echocardiography, cardiac tissue morphology and ...

AIMS: Hypertrophic cardiomyopathy (HCM) is a frequent cause of sudden cardiac death (SCD) due to exercise-related ventricular arrhythmias (ERVA); however the pathological substrate is uncertain. The aim was to determine the prevalence of ERVA and their relation with fibrosis as determined by cardiac magnetic resonance imaging (CMR) in carriers of an HCM causing mutation. METHODS: We studied the...

Cardiac fibrosis is a major cause of heart failure. MicroRNAs (miRs) are important epigenetic regulators of cardiac function and cardiovascular diseases, including cardiac fibrosis. This study aimed to explore the role of miR-503 and its mechanisms in regulating cardiac fibrosis. miR-503 was found up-regulated in the mouse LV tissues subjected to transverse aortic constriction (TAC) and in neon...

AIMS Epidemiological and interventional studies have suggested a protective role for vitamin D in cardiovascular disease, and basic research has implicated vitamin D as a potential inhibitor of fibrosis in a number of organ systems; yet little is known regarding direct effects of vitamin D on human cardiac cells. Given the critical role of fibrotic responses in end stage cardiac disease, we exa...

Dysferlin is a sarcolemmal protein present in muscle cells. It responsible for membrane repair. gene (DYSF) mutation, resulting deficiency this protein, termed dysferlinopathy. Clinically, it manifests as early adulthood onset of weakness with markedly elevated creatine kinase levels. The main phenotypes are limb-girdle muscular dystrophy type 2B (LGMD2B), affecting proximal muscles, and Miyosh...

Advances in donor matching and immunosuppressive therapies have decreased the prevalence of acute rejection of cardiac grafts; however, chronic rejection remains a significant obstacle for long-term allograft survival. While initiating elements of anti-allograft immune responses have been identified, the linkage between these factors and the ultimate development of cardiac fibrosis is not well ...