The plant mitochondrial protein alternative oxidase catalyses dioxygen dependent ubiquinol oxidation to yield ubiquinone and water. A structure of this protein has previously been proposed based on an assumed structural homology to the di-iron carboxylate family of proteins. However, these authors suggested the protein has a very different topology than the known structures of di-iron carboxyla...

This critical review presents a comprehensive study of transition-metal carboxylate clusters which may serve as secondary building units (SBUs) towards construction and synthesis of metal-organic frameworks (MOFs). We describe the geometries of 131 SBUs, their connectivity and composition. This contribution presents a comprehensive list of the wide variety of transition-metal carboxylate cluste...

Siderophores are divided to 2 main structural groups: hydroxamates and catecholates (Drechsel et al. 1995). Hydroxamate siderophores are produced both by bacteria and fungi, while catecholates are reported to the produced only by bacteria (Messenger and Ratledge, 1985). A third group of siderophores the carboxylate (= complexone) type has been reported to be produced exclusively by fungi belong...

The ability of BT-SCF 3 and related 2-(fluoroalkylthio)benzothiazolium salts to activate tetrahydrofuran (THF) has been investigated. In the presence carboxylate nucleophiles, ring-opening polymerization reactions affording various fluorinated non-fluorinated polyethers are observed. Moreover, in absence a carboxylate, activation by benzothiazolium allows for α-deprotonation THF strong external...

We report a strategy of conjugating CPT to the terminal carboxylate group of polylactide (PLA) with a facile hydrolysable amino ester linker via a controlled polymerization method. The obtained CPT-N-PLA conjugates were able to self-assemble into 50-100 nanometer-sized conjugates (NCs) with desired in vitro physicochemical properties and showed enhanced in vivo therapeutic efficacy against Lewi...

The interaction between the Streptomyces R61 penicillin-sensitive DD-peptidase and deacetyl-cephalosporin C or its lactone derivative has been studied at different pH values. The results show the importance of an enzyme group of pK g 9 which might form an ion pair with the free carboxylate of the former compound. This electrostatic interaction is shown to contribute to the formation of the firs...

A 1H NMR study of histidine hydrochloride dissolved in water/dimethyl sulfoxide mixtures gives evidence that dimethyl sulfoxide is able to induce a proton transfer from the imidazolinium nitrogens (mainly N3) to the carboxylate group when its mole fraction becomes greater than 42%. The new tautomeric equilibrium AH2++- in equilibrium AH2+ is quantitatively studied as a function of the solvent c...

PURPOSE Oseltamivir is widely used in the treatment and prophylaxis of influenza A and B viral infections. It is ingested as an oral prodrug that is rapidly metabolized by carboxylesterase 1 (CES1) to its active form, oseltamivir carboxylate. Dexamethasone is also used in the treatment of acute respiratory distress syndrome, a severe complication of influenza; however, its influence on the phar...

A novel method for the preparation of (±)-methyl 1,1a,2,7b-tetrahydro-2-oxocyclopropa[c] chromene-1a-carboxylate has been developed. The cyclopropanation of methyl coumarin-3-carboxylate provided title compound in moderate yield by dropwise treatment with 1.5 equiv. of dimethylsulfoxonium methylide over 6 h. The structure of the newly synthesized compound was determined using 1H-, 13C-NMR, IR a...

The aim of this study was to analyse polar lipids of Candida species isolated from Ahwaz (Iran) by Fast Atom Bombardment Mass Spectrometry (FAB MS). Nine isolates of Candida Sp. were identified by growth at 45°C, production of chlamydoconidia on cornmeal agar, colonial colour on CHROMagar Candida, germ tube production and ID 32C kits. Then polar lipids were extracted from freeze-dried cult...