Sulfotransferase (SULT) function has been well studied in healthy human subjects by quantifying mRNA and protein expression and determining enzyme activity with probe substrates. However, it is not well known if sulfotransferase activity changes in metabolic and liver disease, such as diabetes, steatosis, or cirrhosis. Sulfotransferases have significant roles in the regulation of hormones and e...

On an anatomical basis, cornea may be divided into three major parts: the fibrous stroma, the overlying epithelium, and endothelium. Epithelial and endothelial cells contribute approximately 20% of the total wet weight of beef cornea, and their integrity is essential for stromal maintenance (1). Of the three major parts of cornea, epithelial cells have the highest oxygen consumption that can be...

Aryl sulfotransferase (AST) IV (also named tyrosine-ester sulfotransferase and ST1A1) is a major phenol sulfotransferase in the rat, and it catalyzes the sulfation of many drugs, carcinogens, and other xenobiotics that contain phenol, benzylic alcohol, N-hydroxy arylamine, and oxime functional groups. Previous work discovered a stereospecificity of AST IV toward the enantiomers of 1,2,3,4-tetra...

Tetrabromobisphenol A (TBBPA) pollution in marine environmental media poses great risks to organisms due its potential endocrine-disrupting effects. However, limited attention of TBBPA’s effects has been paid on invertebrates. In this work, the reproductive TBBPA were evaluated by observing gametes development, quantifying gender-specific gene expression, and determining vertebrate sex hormones...

Available evidence suggests that the antischistosomal drug oxamniquine is converted to a reactive ester by a schistosome enzyme that is missing in drug-resistant parasites. This study presents data supporting the idea that the active ester is a sulfate and the activating enzyme is a sulfotransferase. Evidence comes from the fact that the parasite extract loses its activating capability upon dia...

Sulfotransferase (SULT) function has been well studied in healthy human subjects by quantifying mRNA and protein expression and determining enzyme activity with probe substrates. However, it is not well known if sulfotransferase activity changes in metabolic and liver disease, such as diabetes, steatosis, or cirrhosis. Sulfotransferases have significant roles in the regulation of hormones and e...