We hypothesized that lacosamide modulates voltage-gated sodium channels (VGSCs) at clinical concentrations (32-100 muM). Lacosamide reduced spiking evoked in cultured rat cortical neurons by 30-s depolarizing ramps but not by 1-s ramps. Carbamazepine and phenytoin reduced spike-firing induced by both ramps. Lacosamide inhibited sustained repetitive firing during a 10-s burst but not within the ...

Leviteracetam (LEV) is a novel antiepileptic drug with improved tolerance and safety, while carbamazepine (CBZ) represents classical antiepileptic drugs. So far, a systemic comparison of the efficacy and side effects of these two drugs is lacking. A literature review on the comparison of leviteracetam versus carbamazepine for patients with epilepsy was performed up to September 2013 using PubMe...

background :reproductive endocrine disorders and sexual dysfunction are common among men with epilepsy. we investigated sexual hormone serum levels among men with newly diagnosed epilepsy, before starting any antiepileptic drug (aed), and then after starting carbamazepine (cbz), to determine the role and effects of epilepsy versus cbz in creating reproductive endocrine disorders.   methods : in...

Carbamazepine is a crucial medication used to treat nervous system disorders, and its low level of absorption in the human body suggests that significant amount it may be present sewage water. Consequently, this pioneering research deals with synthesis application luminescent sensor based on rhodamine 6 G-modified bifunctional silica particles for determination carbamazepine. The sensing materi...

An 88-year-old man was diagnosed with trigeminal neuralgia, and treatment of carbamazepine 200 mg/day was initiated. About 6 weeks later, the patient developed a skin rash accompanied by fever. He was admitted to hospital and diagnosed with drug-induced hypersensitivity syndrome (DIHS) caused by carbamazepine. Oral carbamazepine treatment was stopped, but blood tests showed acute liver and acut...

The long-term efficacy and safety of sodium valproate and carbamazepine in adult outpatients with newly diagnosed primary generalised or partial and secondarily generalised seizures were compared in a randomised, open, multicentre study at 22 neurology outpatient clinics. Patients were randomised to oral sodium valproate (Epilim EC enteric coated 200 mg tablets twice daily, n = 149) or oral car...