Previously, we have developed a novel porous hydroxyapatite/poly l-lactic-co-caprolactone (HA/PLCL) composite sandwich beam as new scaffold material for bone regeneration. This work presents the study of bending fracture mechanisms and microdamage L-lactic-acid (HA/PLLA) beam, in comparison to previous HA/PLCL beam. Both beams were fabricated using method which single layered between two polyme...

Abstract ε-Caprolactone is a monomer of poly(ε-caprolactone) which has been widely used in tissue engineering due to its biodegradability and biocompatibility. To meet the massive demand for this monomer, an efficient whole-cell biocatalytic approach was constructed boost ε-caprolactone production using cyclohexanol as substrate. Combining alcohol dehydrogenase (ADH) with cyclohexanone monooxyg...

PURPOSE The purpose of this preliminary and descriptive study was to evaluate a biodegradable drug delivery system in combination with an innovative ceramic implant. METHODS The delivery of gentamicin of standardized samples was measured in the laboratory using ultra-high-performance liquid chromatography. Biocompatibility and biodegradation of the materials was investigated in an animal expe...

Objectives We aimed to develop a sustained release system for an anti-TNFa drug in treatment of chronic inflammatory arthritis. A novel form of intra-articularly injectable etanercept (ETN) loaded poly(ε-caprolactone) (PCL) or methoxy poly(ethylene glycol)-poly(ε-caprolactone)methoxy poly(ethylene glycol) (MPEG-PCL-MPEG) microspheres (patent pending) were prepared to provide long term controlle...

A new class of salicylaldiminato tin(II) catalysts having different alkoxy side chains has been developed. The ligands were modified to have different lengths and flexibilities such as –(CH2)2– (2a), –(CH2)3– (2b), –(ortho-C6H4)CH2– (2c) and –(CH2)2–O–(CH2)2– (2d). Complexes 2a, b were characterized crystallographically revealing a more constrained environment around the metal in complex 2a. Th...