Diffusing capacity of the lungs imposes a theoretical limit to oxygen consumption, causing oxygen saturation of arterial blood to fall sharply if this limit is approached (1). The diffusing surface of the normal lung is so large, however, that at sea level oxygen capacity of the blood and the cardiac output rather than diffusing capacity create the major bottleneck to oxygen transport (2). Diff...

A combination of experimental, imaging, and modeling techniques were applied to investigate the pore-scale transport and surface reaction controls on calcite dissolution under elevated pCO2 conditions. The laboratory experiment consisted of the injection of a solution at 4 bar pCO2 into a capillary tube packed with crushed calcite. A high resolution pore-scale numerical model was used to simula...

We have developed a novel mapping software package to reconstruct microvascular networks in three dimensions (3-D) from in vivo video images for use in blood flow and O2 transport modeling. An intravital optical imaging system was used to collect video sequences of blood flow in microvessels at different depths in the tissue. Functional images of vessels were produced from the video sequences a...

To address the hypothesis that functional changes in tissue transport can be related to structural alterations, we combined mathematical modeling with in vivo experimentation. The model concept includes interstitial diffusion and removal by a distributed microvasculature. Transport of solute and water across the peritoneum is measured via a plastic chamber affixed to the abdominal wall of anest...

FROM MULTIPLE CAPILLARIES TO SKELETAL MUSCLE TISSUE MICH ELE S. TITCOMBE AND MICHAEL J. WARD1 Abstract A mathematical model of the transport of oxygen from capillaries to skeletal muscle tissue is a di usion problem in a two-dimensional, bounded domain with Neumann and mixed boundary conditions. We consider N capillaries of small but arbitrary crosssectional shape and demonstrate that, for N > ...

Diffusing capacity of the lungs imposes a theoretical limit to oxygen consumption, causing oxygen saturation of arterial blood to fall sharply if this limit is approached (1). The diffusing surface of the normal lung is so large, however, that at sea level oxygen capacity of the blood and the cardiac output rather than diffusing capacity create the major bottleneck to oxygen transport (2). Diff...

Oxygen transport from capillary networks in muscle at a high oxygen consumption rate was simulated using a computational model to assess the relative efficacies of sprouting and splitting modes of angiogenesis. Efficacy was characterized by the volumetric fraction of hypoxic tissue and overall heterogeneity of oxygen distribution at steady state. Oxygen transport was simulated for a three-dimen...

the phenomenological model of khossravi and connors (1992) has been adopted to calculate the electrophoretic mobility of drugs at different concentrations of solvents in a binary mixture. the accuracy and predictability of the model have been evaluated employing 14 experimental data sets by using average percentage mean deviation (apmd). the obtained apmd for correlative and predictive studies ...

Expression and transport activity of Sodium-dependent Vitamin C Transporter 2 (SVCT2) was shown in various tissues and organs. Vitamin C was shown to be cerebroprotective in several animal models of stroke. Data on expression, localization and transport activity of SVCT2 after cerebral ischemia, however, has been scarce so far. Thus, we studied the expression of SVCT2 after middle cerebral arte...

To investigate how water flow and interstitial pressure change in tissue during a peritoneal dwell with isotonic fluid, we developed a mathematical model of water transport in the tissue. Transport through muscle alone (M) and through muscle with intact skin (MS) were considered for the rat abdominal wall, using various parameters for muscle and skin. Based on the concept of distributed capilla...