Vasculogenic mimicry (VM) is the release of angiogenic factors from tumor cells, leading to morphological changes, migration and proliferation vascular endothelial ultimately neovascularization. The presence VM has been identified in breast cancer, formation also gives cancer a poor prognosis such as drug resistance metastasis. authors focus on role PI3K/Akt signaling pathway, hypoxia-inducible...

Drug Screening In article number 2207194, Mengsu Yang and co-workers design a high throughput microfluidic chip that could achieve multi-function drug screening against collective migration of cancer cells under confined environment. Using this device, three new compounds significantly inhibit are found: MA-5, SB-705498 diphenyleneiodonium chloride (DPI). These target mitochondria, actin polyme...

Specific delivery of therapeutic agents to solid tumors and their bioavailability at the target site are the most clinically important and challenging goals in cancer therapy. Liposomes are promising nanocarriers and have been well investigated for cancer therapy. In spite of preferred accumulation in tumors via the enhanced permeability and retention (EPR) effect, inefficient drug release at t...

Cancer is a big global problem and is one of the top and main causes of mortality in developed countries. Many of the current treatments and anticancer therapeutics have problems with severe side effects and on the other hand, the drug resistance is also another obstacle in the cancer chemotherapy. Hence, there is a strong demand for the discovery and development of effective new antineopla...

Tamoxifen is routinely used for treatment of Estrogen-positive breast carcinoma. Approximately, 50% of patients with metastatic cancer will develop resistance to Tamoxifen. In this research, Tamoxifen was combined with the anti-cancer compound Curcumin. Diblock nanopolymer was used to package the new formulation of Curcumin and Tamoxifen. Anti-cancer efficacy of the obtained compound was evalua...

pancreatic cancer (pc) is a progressive, fatal disease with a high degree of malignancy. more than 40000 peoplediefrom this cancer annually in the united states. as a multifactorial condition, pc has a complex nature, and there are several genes and signalingpathwaysimplicated in pc pathogenesis and progression. there are diffèrent mutations in master genesincludingtumorsuppressors and oncogene...

normal 0 false false false microsoftinternetexplorer4 the association of solid tumors with idiopathic thrombocytopenic purpura (itp) is rare. however, there have been some case reports indicating an association between breast cancer and itp. in this article four patients with breast cancer and itp are mentioned. the diagnosis of breast cancer was based on the results of biopsy or surgical sampl...

EGFR is a key player in the signalling cascades of various kinds cancers and tyrosine kinase inhibitors block signalling. Natural products have long been used as candidates for therapy management cancer. Violacein, bacterial pigment, has known its numerous biological applications such antimicrobial, antileishmanial, antiviral, well antitumoral. Computational studies concluded that it may activi...