New HPLC-UV method (method A), for simultaneous determination of metformin (MET) and canagliflozin (CANA), was developed and compared to another novel UPLC-UV method (method B) in their tablet combination. Concerning method A, isocratic separation was done by C18 column (100 mm × 2.1 mm, 3 μm) using methanol and 0.03 M phosphate buffer (75 : 25, v/v) at pH 3.2 as a mobile phase. Meanwhile, chro...

Abstract Background Diabetes clinical trials have shown SGLT inhibition improves cardiovascular outcomes, yet the mechanism is not fully understood. Hyperglycemia a common finding in diabetic and non-diabetic patients presenting with ACS powerful predictor of prognosis mortality. The role hyperglycemia ischemia-reperfusion injury (IRI) understood, whether Sodium Glucose Co-Transporter 1 (SGLT1)...