In this paper, we propose a new physical synthesis methodology, PDL, which relaxes the timing constraints to obtain best optimality in terms of layout quality and timing quality. It provides a common database for delay calculation, logic optimization, placement, and routing tools so that they can work and interact closely. We present results on industrial circuits showing the efficacy of this m...

This paper discusses a statistical effect of performance optimization to uncertainty in circuit delay. Performance optimization has an effect of balancing the delay of each path in a circuit, i.e. the delay of long paths are shortened and the delay of short paths are lengthened. In these path-balanced circuits, the uncertainty in circuit delay, which are caused by delay calculation error, manuf...

According to our present understanding many J/c production processes proceed through a colored cc̄ state followed by the emission of soft particles in the quarkonium rest frame. The kinematic effect of soft particle emission is usually a higher-order effect in the non-relativistic expansion, but becomes important near the kinematic end point of quarkonium energy ~momentum! distributions. In an i...

One-sample and two-sample t-tests are commonly used in analyzing data from clinical trials in comparing mean responses from two drug products. During the planning stage of a clinical study, a crucial step is the sample size calculation, i.e., the determination of the number of subjects (patients) needed to achieve a desired power (e.g., 80%) for detecting a clinically meaningful difference in t...

The modeling of the severe acute respiratory syndrome coronavirus helicase ATPase catalytic domain was performed using the protein structure prediction Meta Server and the 3D Jury method for model selection, which resulted in the identification of 1JPR, 1UAA and 1W36 PDB structures as suitable templates for creating a full atom 3D model. This model was further utilized to design small molecules...

inflammation of blood vessels is a characteristic feature of kawasaki disease. neutrophils play a key role in the inflammatory responses where movement of neutrophils toward the site of inflammation depends on cd11b/cd18 expression as adhesion molecules on these cells. the purpose of this study was to investigate cd11b/cd18 expression in patients with kawasaki disease upon diagnosis and after t...

RESUMO – A computer aided product design (CAPD) tool was developed aiming to find bio-based molecules that match a set of desired properties. Molecules are represented by molecular graphs that are split into basic groups by automatic decomposition methods. These groups are further used for property predictions using Group Contributions methods by the property calculation component, a Dynamic-Li...

In this Chapter we introduce the description of single and pair particle static properties of liquid crystals, and discuss their calculation from computer simulations. We also briefly describe the calculation of dynamic properties from molecular dynamics simulations using Linear Response theory. 1. Single particle properties We consider a system of N molecules at certain specified thermodynamic...

We discuss new results in QCD obtained with string-based methods. These methods were originally derived from superstring theory and are significantly more efficient than conventional Feynman rules. This technology was a key ingredient in the first calculation of the one-loop five-gluon amplitude. We also present a conjecture for a particular one-loop helicity amplitude with an arbitrary number ...

Simulation of gate circuits is an efficient method of detecting hazards and oscillations that may occur in the presence of gate and wire delays. Ternary simulation, introduced by Eichelberger in 1965, consists of two algorithms, called A and B, and its results are well understood. Ternary simulation has been generalized by Brzozowski and Ésik in 2003 to an infinite algebra C and finite algebras...