The regulation of Ca in human body is performed by Ca-ATPase. The affinity of erythrocyte plasma membrane Ca-ATPase (PMCA) was examined for three different porphyrin compounds, Tetraphenylporphinesulfonate (TPPS), 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) Chloride (FeTPPS) and 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) nitrosyl Chloride (FeNOTPPS), by en...

Microalgae are an untapped source of bioactive compounds with various biotechnological applications. Several species industrially produced and commercialized for the feed or cosmetic industries, however, other applications in functional food pharmaceutical markets can be foreseen. In this study, nine industrial/commercial were evaluated vitro antioxidant, calcium-chelating, anti-tumoral, anti-i...

Since the disclosure of Biginelli reaction by the chemist Pietro Biginelli, functionalized 3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs) have emerged as prototypes for the design of compounds with a broad variety of biological activities. This mini-review describes over 100 Biginelli adducts demonstrated to be promising anticancer, inhibitors of calcium channel, anti-inflammatory, antimicrobi...

Abstract Heteronuclear calcium–iron carbonyl cation complexes in the form of [CaFe(CO) n ] + ( =5–12) are produced gas phase. Infrared photodissociation spectroscopy conjunction with quantum chemical calculations confirm that =10 complex is coordination saturated ion where a Fe(CO) 4 fragment bonded Ca(CO) 6 through two side‐on bridging ligands. Bonding analysis indicates it best described by b...

in order to investigate the effects of dimethylamino substituent at position 2 of the dihydropyridine nucleus on activity, starting from dialkyl l ,4-dihydro-2,6-dimethyl-4- (l-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (5a-f) which their synthesis and effects as calcium channel antagonist on guinea-pig ileum has been reported previously, dialkyl l,4-dihydro-2-[2-(dimethylamino...

BACKGROUND T-type calcium channels are important contributors to signaling in the primary afferent pain pathway and are thus important targets for the development of analgesics. It has been previously reported that certain piperazine-based compounds such as flunarizine are able to inhibit T-type calcium channels. Thus, we hypothesized that novel piperazine compounds could potentially act as ana...