background: vitamin d, especially its most active metabolite 1,25-dihydroxyvitamin d₃(vit d) is essential in regulating a wide variety of biologic processes, such as regulating mesangial cell activation. the objective of this study was to assess the histopathological changes of effectiveness of vit d as a protective agent against radiation induced lung injury. materials and methods: eighteen wi...

synthesis that accompanies renal insufficiency results Introduction in increased parathyroid stimulation from each of the principal modulators, namely decreased calcium, In this review we discuss some of the clinical implicaincreased phosphate, and decreased calcitriol. This tions of progress in our understanding of the action of scenario is further complicated by the blunted target vitamin D a...

Estrogen deficiency and declining calcium absorption due to reduced calcitriol levels or intestinal resistance to calcitriol, are important factors in the pathogenesis of age-related bone loss. The main objective of this study was to examine the effect of estrogen and 1,25-dihydroxyvitamin D therapy given individually or in combination on bone loss in elderly women. Four hundred eighty-nine eld...

Vitamin D insufficiency is prevalent in chronic kidney disease (CKD) and associated with secondary hyperparathyroidism (SHPT) and increased risk of bone and vascular disease. Unfortunately, supplementation of stage 3 or 4 CKD patients with currently recommended vitamin D2 or D3 regimens does not reliably restore serum total 25-hydroxyvitamin D to adequacy (≥30ng/mL) or effectively control SHPT....

Dietary calcium plays a key role in the regulation of energy metabolism and obesity risk. This appears to be mediated primarily by dietary calcium modulation of circulating calcitriol, which in turn regulates adipocyte intracellular calcium ([Ca2+]i). Increased [Ca2+]i stimulates lipogenic gene expression and activity and inhibits lipolysis, resulting in increased adipocyte lipid accumulation. ...

BACKGROUND The aim of this analysis was to estimate biochemical parameters and the costs of treatment of secondary hyperparathyroidism (SHPT) in a subpopulation of the FARO-2 study. METHODS The FARO-2 observational study aimed at evaluating the patterns of treatment for SHPT in naïve hemodialysis patients. Data related to pharmacological treatments and biochemical parameters (parathyroid horm...

1719 times a week were given i.v. calcitriol at the end of each and basal PTH as well as carboxy-terminal telopeptide of collagen I in haemodialysis patients. dialysis session. In the first month the received 1 mg per session , then 1.5 mg in the following month, and a mean of Furthermore, the lack of correlation between IL-6 and serum PTH, as well as TRAP values after calcitriol treatment, 2.1...

Calcitriol, the active form of vitamin D3, can regulate the gene expression through the binding to the nuclear receptor VDR, but it can also display nongenomic actions, acting through a membrane-associated receptor, which has been discovered as the disulfide isomerase ERp57. The aim of our research is to identify the binding sites for calcitriol in ERp57 and to analyze their interaction. We fir...

The study aimed at evaluating the effects of calcitriol and of its analogues on the proliferation of TT and rMTC cells (human and rat line tumour cells originating from thyroid medullary carcinoma) and at examining the effects of the substances on the secretion of the principal hormones of the cells, calcitonin (CT) and calcitonin gene-related peptide (CGRP). Cells of thyroid medullary carcinom...

BACKGROUND The vitamin D metabolizing enzymes 25-, 1α- and 24-hydroxylase are expressed in malignant cells of the cervix and the ovaries. The aim of this study was to obtain further information about the regulation of the aforementioned enzymes by vitamin D, calcidiol and calcitriol in cervical and ovarian cancer. MATERIALS AND METHODS The human cervical adenocarcinoma cell line HeLa and the ...