BACKGROUND A number of studies have reported relationships of CYP2E1 RsaI/PstI polymorphisms with susceptibility to lung cancer in Chinese population. However, the epidemiologic results have been conflictive rather than conclusive. The purpose of this study was to address the associations of CYP2E1 RsaI/PstI polymorphisms with lung cancer risk in Chinese population comprehensively. MATERIALS ...

STUDY DESIGN Anatomical study. PURPOSE To evaluate the anatomy of the C2 lamina for translaminar screw placement based on computerized tomographic measurements. OVERVIEW OF LITERATURE C2 translaminar screw insertion is a novel technique for atlanto-axial fixation. The risk of vertebral artery injury can be decreased by this technique. However, a large series of anatomical studies on C2 anat...

Published data on any association between the CYP2E1 RsaI/PstI (c1/c2) polymorphism and liver cancer risk among east Asians are inconclusive. The aim of this Human Genome Epidemiology (HuGE) review and meta- analysis was to derive a more precise estimation of the relationship. A literature search of Pubmed, Embase, Web of science and CBM databases from inception through July 2012 was conducted....

The sphingomyelin-derived messenger ceramides provoke neuronal apoptosis through caspase-3 activation, while the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) promotes neuronal survival and inhibits caspase-3 activity. However, the mechanisms leading to the opposite regulation of caspase-3 by C2-ceramide and PACAP are currently unknown. Here, we show that PACAP prevent...

The currently available data on the distribution of C2 fracture subtypes is sparse. This study was designed to identify the proportions of the second cervical vertebra (C2) fracture subtypes and to present age and gender specific incidences of subgroups. A dataset of all patients treated between 2002 and 2014 for C2 fractures was extracted from the regional hospital information system. C2 fract...

NK cells are regulated by inhibiting and activating cell surface receptors. Most inhibitory receptors recognize MHC class I Ags and protect healthy cells from NK cell-mediated autoaggression. However, certain activating receptors, including the human activating killer cell Ig-like receptor (KIR) 2DS1, also recognize MHC class I. This fact raises the question of how NK cells expressing such acti...

Enterovirus 71 (EV-71) is involved in epidemics of hand, foot, and mouth disease (HFMD) and has been reported to occur with severe neurological complications in eastern and south-east Asia. In other geographical areas, the transmission of this virus is poorly understood. We used large sequence datasets (of the gene encoding the viral protein 1, VP1) and a Bayesian phylogenetic approach to compa...

The C2 domain is a membrane-targeting domain found in many cellular proteins involved in signal transduction or membrane trafficking. The majority of C2 domains co-ordinate multiple Ca(2+) ions and bind the membrane in a Ca(2+)-dependent manner. To understand the mechanisms by which Ca(2+) mediates the membrane binding of C2 domains, we measured the membrane binding of the C2 domains of group I...

The articles [9], [1], [3], [4], [6], [5], [2], [7], and [8] provide the notation and terminology for this paper. We use the following convention: q, r, c, c1, c2, c3 are quaternion numbers and x1, x2, x3, x4, y1, y2, y3, y4 are elements of R. 0H is an element of H. 1H is an element of H. Next we state several propositions: (1) For all real numbers x, y, z, w holds 〈x, y, z, w〉H = x+y · i+ z · ...