The most frequent genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia is a G 4 C 2 repeat expansion in the C9orf72 gene. This gives rise to translation aggregating dipeptide (DPR) proteins, including poly-GA as abundant species. However, gain toxic function effects have been attributed either DPRs or pathological RNA. Here, we analyzed cellular model relative toxicity Cyt...
