Paracoccidioidomycosis (PCM), one of the most important systemic mycoses in Central and South America, is caused by the dimorphic fungus Paracoccidioides brasiliensis and has a high prevalence in Brazil. Glycoproteins of 43 and 70 kDa are the main antigenic compounds of P. brasiliensis and are recognized by Western blotting by 100 and 96% of PCM patient sera, respectively. In the present study,...

Disruption of iron homeostasis within the central nervous system (CNS) can lead to profound abnormalities during both development and aging in mammals. The radiation-induced polycythaemia (Pcm) mutation, a 58-bp microdeletion in the promoter region of ferroportin 1 (Fpn1), disrupts transcriptional and post-transcriptional regulation of this pivotal iron transporter. This regulatory mutation ind...

The ability of the Parallel Climate Model (PCM) to reproduce the mean and variability of hydrologically relevant climate variables was evaluated by comparing PCM historical climate runs with observations over temporal scales from sub-daily to annual. The domain was the continental U.S, and the model spatial resolution was T42 (about 2.8 degrees latitude by longitude). The climate variables eval...

BACKGROUND Dedifferentiation of chondrocytes remains a major problem for cartilage tissue engineering. Chondrocytes loss differentiated phenotype in in vitro culture that is undesired for repair strategies. The chondrocyte is surrounded by a pericellular matrix (PCM), together forming the chondron. PCM has a positive effect on the maintenance of chondrocyte phenotype during culture in compar...

Building-integrated photovoltaics (BIPVs) are the most promising systems for net-zero energy buildings. However, there few practical cases because of shortcomings, such as lack solar tracking and rapid rise in PV surface temperature. Therefore, methods increasing efficiency BIPVs have been proposed studied. These include using phase change material (PCM) or heat fins, wavelength selection, decr...

There is an increasing interest in developing Phase Change Memory (PCM) based main memory systems. In order to retain the latency benefits of DRAM, such systems typically have a small DRAM buffer as a part of the main memory. However, for these systems to be widely adopted, limitations of PCM such as low write endurance and expensive writes need to be addressed. In this paper, we propose PCMawa...

Abstruct-Research and development of coherent optical fiber communications have been accelerated mainly because of the possibility of receiver sensitivity improvement reaching 20 dB, and partly because of the possibility of frequency-division multiplexing (FDM) with very fine frequency separation. In this paper, recent advances in the research on coherent optical fiber communication systems are...

Use of a phase change material (PCM)-based heat sink in transient thermal management of plastic quad flat package (QFP) electronic devices was investigated experimentally and numerically. Results show that increased power inputs enhance the melting rate as well as the thermal performance of the PCM-based heat sinks until the PCM is fully melted. A three-dimensional computational fluid dynamics ...

Cultured corneal epithelial cells release a factor(s) that stimulates trigeminal neurons to form neurites in vitro. To characterize this trophic effect, conditioned media (serum free, supplemented) from cultures for corneal epithelium, stromal fibroblasts, and endothelium were studied further. Only epithelial conditioned medium (PCM) prolonged neuronal survival and induced neurite outgrowth. Th...