Given the importance of IT investments in today’s organization, firms tend to spend increasing amounts of time and resources to better manage IT projects. However these projects continue to have high failure rates thus highlighting the need for improved risk management. A stream of IS research has focused on identifying several causes of managerial risks. The theory base that has been used in t...

In this study, Sandrio et al. [1] describe their experience with an intraluminal band placed in the main pulmonary artery (PA) in 32 patients over an 8-year period, and advocate its use as optimal palliation for children requiring control of excessive pulmonary artery flow. The technique in itself is not new; Piluiko et al. [2] and Locker et al. [3] both described an identical procedure to the ...

Living systems are perhaps the most fascinating examples of chemistry in action. Molecules assemble into biomachinery that can carry out complex tasks, making life possible. But how did it all begin? This question can be tackled from a geological perspective by surveying the possible conditions under which key biomolecules might have emerged on early Earth. Alternatively, a systems-biology appr...

In the early 1960s, we used the few antiarrhythmic drugs available empirically, presuming that every premature ventricular contraction had to be suppressed. This presumption spurred ever greater effort, much of it going into antiarrhythmic drug development.' Throughout the 1980s, one new drug was being developed about every six months,2 and the number of antiarrhythmic prescriptions rose expone...

species of chameleon, Furcifer labordi, in Madagascar that spends most of its life as an egg. in Madagascar and the American Museum of Natural History in New York, have found a chameleon with a remarkable lifestyle and report the results in the latest issue of the Proceedings of the National Academy of Sciences (published online). Although there are almost limitless theoretical combinations of ...

Part 1 provides Arbib's reflections on the influence of Marc Jeannerod on his career. Part 2 recalls the Mirror System Hypothesis (MSH) for the evolution of the language-ready brain, a theory which emphasizes the role of manual action in grounding language evolution, thus giving one meaning for "language is handy". Part 3 then joins in current debates over the notion of whether or not language ...