A 79-year-old woman presented with hypercalcemia and a mediastinal mass identified by computed tomography scan. Further imaging revealed several intracranial lesions that were not intraparenchymal, as well as a large periaortic mass with diffuse abdominal lymphadenopathy. A biopsy of the mediastinal mass yielded a diagnosis of B-cell lymphoma, unclassifiable, with features intermediate between ...

Burkitt lymphoma (BL) is the most frequent non-Hodgkin lymphoma in pediatric patients, accounting for approximately 34% of the cases of lymphoma in children. This subtype of non-Hodgkin lymphoma was first described in 1958 as a monoclonal proliferation of B cell lymphocytes. Cardiac involvement of BL in association with osseous compromise and lymphadenopathy is rare and poorly documented. We re...

We report the case of an HIV-infected young men with neuro-toxoplasmosis localized in the spinal cord. The patient received chemotherapy and immunotherapy for Burkitt lymphoma one year before. At the time of the diagnosis of toxoplasmosis, he was on prophylaxis with trimethoprim and sulfamethoxazole and in complete remission of Burkitt lymphoma. The CD4+ T cell count was 270/μl and the HIV vire...

Trials to reintroduce chloroquine into regions of Africa where P. falciparum has regained susceptibility to chloroquine are underway. However, there are long-standing concerns about whether chloroquine increases lytic-replication of Epstein-Barr virus (EBV), thereby contributing to the development of endemic Burkitt lymphoma. We report that chloroquine indeed drives EBV replication by linking t...

BACKGROUND There are numerous reports from different countries documenting a change in frequency and profile of lymphomas after the onset of the HIV/AIDS pandemic. In Uganda little is known concerning the distribution of lymphoma subtypes diagnosed at the Department of Pathology, Makerere University College of Health Sciences during this period. OBJECTIVE To examine the frequency and diagnost...

We present a 13.5 year old boy with chronic intussusception that was misdiagnosed as Crohn disease and received treatment for the wrong diagnosis. Because his condition didn’t improve, more work-ups were performed and the radiologic work-ups revealed the diagnosis of a missed intussusception with fistula.We suggest that prolonged intussusception should be considered in the list of differential ...

BACKGROUND Burkitt lymphoma rarely affects the central nervous system and ocular region. Under these conditions, computed tomography and (particularly) magnetic resonance imaging of the skull increase the diagnostic accuracy, as they objectively show the topography of lesions and the effect of neoplasia on structures. CASE REPORT We report here the case of a 17-year-old male whose initial cli...

Of 14 lines of human leukocytes, designated LK1D, LK57, LK60, LK63, LK87A, LK91, SK-L1, SK-L3, SK-L4, SK-L5, SK-L6, SK-L7, RPMI 7216, and RPMI 7466, all were classi cally diploid or very near-diploid when first examined. All but one showed occasional No. 10 chromosomes with the near terminal secondary constriction seen in Burkitt lymphoma cells in vitro. Nine lines showed accentuation of second...

A particular translocation between chromosomes 8 and 14 has been found repeatedly in cytogenetic studies of Burkitt lymphoma, both of African and non-African origin. We report here our findings in cytogenetic studies of direct tumor preparations from 18 non-African Burkitt lymphoma patients, 9 of whom also had cell lines available for study. A t(8;14) was found in direct tumor material in 10 of...

A case of sporadic Burkitt lymphoma (sBL) presenting with jaw and lid involvement in a diabetic adult African American female and a review of adult orbital Burkitt lymphoma cases are presented. Lid edema, visual loss, ophthalmoparesis, proptosis, and sinusitis progressed over 4 weeks despite antibiotic and steroid treatment. Upper lid biopsy histopathological evaluation and immunophenotyping re...