Femtosecond laser irradiation followed by chemical etching (FLICE) with hydrogen fluoride (HF) is an emerging technique for the fabrication of directly buried, three-dimensional microfluidic channels in silica. The procedure, as described in literature, consists of irradiating a silica slab followed by chemical etching using hydrogen fluoride. With aqueous HF the etching process is diffusion-li...

Annexin V is a potent anticoagulant protein which is soluble in water but associates with membranes in the presence of Ca+* [I]. It is capable of forming voltage-gated ion channels which are selective for Ca" [2], but are also permeant to other divalent ions and Li', Cs' and Na'. X-ray crystal structures of the protein revealed a central pore running through the molecule, containing buried char...

A numerical simulation is carried out to study the effect of the thin metal outer case of an antitank mine and the top air gap of an antipersonnel mine on the passive infrared imaging signature. In addition, an antipersonnel surface mine is also analyzed in the present investigation to show its effect on the soil thermal content. The effect of shortand long-wavelength radiation as well as the c...

Protein-protein interactions play key roles in many cellular processes and their affinities and specificities are finely tuned to the functions they perform. Here, we present a study on the relationship between binding affinity and the size and chemical nature of protein-protein interfaces. Our analysis focuses on heterodimers and includes curated structural and thermodynamic data for 113 compl...

BACKGROUND Over the last several decades, reconstruction of the head and neck oncologic defect has been revolutionized by the use of microvascular free tissue transfer. The majority of these defects can be reconstructed with the ability to visually monitor the flap, to intervene as soon as vascular compromise becomes evident. Occasionally, it is necessary to use a flap that has no visual extern...

The aquaporin family of channels was defined based on the inhibition of water transport by mercurial compounds. Despite the important role of mercurials, little is known about the structural changes involved upon mercury binding leading to channel inhibition. To elucidate the mechanism we designed a mutant, T183C, of aquaporin Z (AqpZ) patterned after the known mercury-sensitive site of aquapor...

Fluidic resonators with integrated microchannels (hollow resonators) are attractive for mass, density, and volume measurements of single micro/nanoparticles and cells, yet their widespread use is limited by the complexity of their fabrication. Here we report a simple and cost-effective approach for fabricating hollow microtube resonators. A prestructured silicon wafer is annealed at high temper...

In this paper, we report a new collector-up npn heterojunction bipolar transistor (C-up HBT) which employs a p-type doping buried layer inserted between extrinsic emitter and subemitter for current confinement. A theoretical study is performed to verify the functionality of the p-type doping buried layer using a two-dimensional device simulator. The structural parameters of the device and bias ...

This study examined pig carcasses buried at two different depths, 30 and 60 cm, to determine if insects were able to colonize buried carcasses, when they arrive at each depth, and what fauna were present over seven sampling dates to establish an insect succession database on buried carrion in East Lansing, MI. Thirty-eight pigs were buried, 18 at 30 cm and 20 at 60 cm. Four control carcasses we...

Buried Fiber Optic Intrusion Sensor. (May 2004) Eric William Maier, B.S., Texas A&M University Chair of Advisory Committee: Dr. Henry Taylor A distributed fiber optic intrusion sensor capable of detecting intruders from the pressure of their weight on the earth’s surface was investigated in the laboratory and in field tests. The presence of an intruder above or in proximity to the buried sensor...