Buccal patches of salbutamol sulfate were prepared using five different water soluble polymers in various proportions and combinations using PEG-400/PG as plasticizers. A 32 full factorial design was used to design the experiments for each polymer combination. Patches were laminated on one side with a water impermeable backing layer for unidirectional drug release. The thickness of medicated pa...

objective(s) physiological changes in the body may be utilized as potential triggers for controlled drug delivery. based on these mechanisms, stimulus-responsive drug delivery has been developed. materials and methods in this study, a kind of poly (n-isopropylacrylamide-acrylamide) membrane was prepared by radical copolymerization. changes in swelling ratios and diameters of the membrane were i...

conclusions this study demonstrated that physicochemical properties, in vitro release and rat intestine permeability were dependent upon the contents of s/c, water and oil percentage in formulations. background self-emulsifying drug delivery system is an isotropic mixture of natural or synthetic oils, non-ionic surfactants or, one or more hydrophilic solvent and co-solvents/surfactant and polym...

objective(s): the aim of this work was to prepare and characterize magnetic nanoparticles (mnps) as theranostic system to act simultaneously as drug carrier and mri contrast agent. chitosan-coated mnps (cmnps) were prepared and loaded with silymarin. silymarin-loaded cmnps were characterized with various techniques and their potential as mri contrast agent was also evaluated. materials and meth...

Objective: Chlorzoxazone (CLZ) is centrally acting skeletal muscle relaxant. It is insoluble in water, so employed for the formation of solid dispersions (SD) as a means to enhance the dissolution rate, and carrier selected was polyethylene glycol 6000 (PEG 6000). Methods: The SDs were prepared by different methods and characterized by in vitro drug release, drug content, fourier transform infr...

Oral films, a promising novel drug delivery system, are a strip of single or multilayered, mucoadhesive or non-mucoadhesive, thin polymeric films that are intended to deliver active therapeutic moieties either locally or systemically in oral cavity through sublingual, buccal, palatal, or gastrointestinal absorption [1-3]. In general, films are known by several names including but not limited to...

In recent years, signiÞ cant interest has been shown in the development of novel bioadhesive dosage forms for mucosal delivery of drugs that attempt to overcome these limitations1. A bioadhesive dosage form necessitates the use of mucoadhesive polymers to adhere to mucosa and withstand salivation, tongue movement and swallowing for signiÞ cant period of time2. High molecular weight polymers are...

Pullulan, a water soluble, bioadhesive and biocompatible biopolymer is used as an efficient matrix for enalapril maleate film preparation. The obtained film contains as much as 67% of enalapril maleate, relative to the initial amount used for experiments. The drug content was evaluated by using 1 H-NMR and UV-vis spectroscopy. The pullulanenalaprilmaleate blends exhibit good physicochemical pro...