نتایج جستجو برای: btk expression

تعداد نتایج: 873168  

Journal: :Experimental Hematology 2022

REIIBP is a t(4;14)-deregulated histone methyltransferase arising from alternative promoter usage within the MMSET locus. Despite sharing identical sequence with C-terminus of MMSET, we found that displayed distinct expression pattern other breakpoint variants and gene products t(4;14) Additionally, can be regulated through microRNAs by another methyltransferase, EZH2 in Dicer-dependent manner....

Journal: :Blood 2015
Baohua Sun Bhavin Shah Warren Fiskus Jun Qi Kimal Rajapakshe Cristian Coarfa Li Li Santhana G T Devaraj Sunil Sharma Liang Zhang Michael L Wang Dyana T Saenz Stephanie Krieger James E Bradner Kapil N Bhalla

Mantle cell lymphoma (MCL) cells exhibit increased B-cell receptor and nuclear factor (NF)-κB activities. The bromodomain and extra-terminal (BET) protein bromodomain 4 is essential for the transcriptional activity of NF-κB. Here, we demonstrate that treatment with the BET protein bromodomain antagonist (BA) JQ1 attenuates MYC and cyclin-dependent kinase (CDK)4/6, inhibits the nuclear RelA leve...

2012
Jack Hutcheson Kamala Vanarsa Anna Bashmakov Simer Grewal Deena Sajitharan Betty Y Chang Joseph J Buggy Xin J Zhou Yong Du Anne B Satterthwaite Chandra Mohan

INTRODUCTION Systemic lupus erythematosus is a chronic autoimmune disease characterized by an abundance of autoantibodies against nuclear antigens. Bruton's tyrosine kinase (Btk) is a proximal transducer of the BCR signal that allows for B-cell activation and differentiation. Recently, selective inhibition of Btk by PCI-32765 has shown promise in limiting activity of multiple cells types in var...

2008
Carmen Spatuzza Marco Schiavone Emanuela Di Salle Elzbieta Janda Marco Sardiello Giuseppe Fiume Olga Fierro Marco Simonetta Notis Argiriou Raffaella Faraonio Rosanna Capparelli Ileana Quinto Giuseppe Scala

Bruton's tyrosine kinase (Btk) is required for B-cell development. Btk deficiency causes X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (Xid) in mice. Btk lacks a negative regulatory domain and may rely on cytoplasmic proteins to regulate its activity. Consistently, we identified an inhibitor of Btk, IBtk, which binds to the PH domain of Btk and down-regulates the Btk...

Journal: :Science signaling 2009
Richard G James Travis L Biechele William H Conrad Nathan D Camp Daniel M Fass Michael B Major Karen Sommer XianHua Yi Brian S Roberts Michele A Cleary William T Arthur Michael MacCoss David J Rawlings Stephen J Haggarty Randall T Moon

Wnts are secreted ligands that activate several receptor-mediated signal transduction cascades. Homeostatic Wnt signaling through beta-catenin is required in adults, because either elevation or attenuation of beta-catenin function has been linked to diverse diseases. To contribute to the identification of both protein and pharmacological regulators of this pathway, we describe a combinatorial s...

Journal: :Immunity 1995
X C Liao D R Littman

Itk is a T cell protein tyrosine kinase (PTK) that, along with Btk and Tec, belongs to a family of cytoplasmic PTKs with N-terminal pleckstrin homology domains. Btk plays a critical role in B lymphocyte development. To determine whether Itk has an analogous role in T lymphocytes, we used gene targeting to prepare mice lacking expression of Itk. Such animals had decreased numbers of mature thymo...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2015
Sutapa Sinha Justin Boysen Michael Nelson Charla Secreto Steven L Warner David J Bearss Connie Lesnick Tait D Shanafelt Neil E Kay Asish K Ghosh

PURPOSE B-cell chronic lymphocytic leukemia (CLL) is an incurable disease despite aggressive therapeutic approaches. We previously found that Axl receptor tyrosine kinase (RTK) plays a critical role in CLL B-cell survival. Here, we explored the possibility of using a high-affinity Axl inhibitor as a single agent or in combination with Bruton's tyrosine kinase (BTK) inhibitors for future clinica...

2012
Hossain M. Nawaz Per Kylsten Noriko Hamada Daisuke Yamamoto C. I. Edvard Smith Jessica M. Lindvall

BACKGROUND A central question within biology is how intracellular signaling pathways are maintained throughout evolution. Btk29A is considered to be the fly-homolog of the mammalian Bruton's tyrosine kinase (Btk), which is a non-receptor tyrosine-kinase of the Tec-family. In mammalian cells, there is a single transcript splice-form and the corresponding Btk-protein plays an important role for B...

, ,

Severe acute respiratory syndrome coronavirus-2 has led to a widespread pandemic whose spread is astonishing, its treatment is uncertain, mortality is significant, and associated socioeconomic complications are uncontrollable. Although little is known about the pathogenesis of the disease, severe cases of COVID-19 are usually associated with cytokine release syndrome and high serum levels of in...

Journal: :Journal of Investigative Dermatology 2022

Since the antigen affinity of B cells varies from cell to cell, functional analysis in each has been difficult technical aspects. Especially autoimmune diseases, promising pathogenic have not adequately studied date because rarity. Here, we analyzed single-cell function autoantigen-reactive systemic sclerosis (SSc). Topo I-reactive were extracted peripheral blood SSc patients. mRNA expression a...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید