نتایج جستجو برای: brucella abos

تعداد نتایج: 6264  

2017
Ali G Alhamada Ihab Habib Anne Barnes Ian Robertson

Sera from 432 small ruminants (335 sheep and 97 goats) from 72 farms in Duhok Province, northern Iraq, were collected to investigate risk factors associated with brucellosis seropositivity. Serum samples were tested using the Rose Bengal test (RBT) and an indirect enzyme-linked immunosorbent assay (iELISA). Using parallel interpretation, RBT and iELISA results showed that 31.7% (95% confidence ...

2010
Göknur TERZİ Nevzat YURDUSEV

The aim of the present study was to determine comparatively the presence of anti-Brucella antibody and Brucella DNA in cow milk. Anti-Brucella antibody was detected by ELISA based on the lipopolysaccharide (LPS) as diagnostic antigen. Besides, the presence of Brucella DNA in milk samples was screened by eryCD gene-targeted PCR and B. abortus DNA was determined by amplification of alkB genes. Fo...

2013
Sebenzile Myeni Robert Child Tony W. Ng John J. Kupko Tara D. Wehrly Stephen F. Porcella Leigh A. Knodler Jean Celli

The intracellular pathogenic bacterium Brucella generates a replicative vacuole (rBCV) derived from the endoplasmic reticulum via subversion of the host cell secretory pathway. rBCV biogenesis requires the expression of the Type IV secretion system (T4SS) VirB, which is thought to translocate effector proteins that modulate membrane trafficking along the endocytic and secretory pathways. To dat...

Journal: :Infection and immunity 2002
Yongqun He Ramesh Vemulapalli Gerhardt G Schurig

The members of the genus Brucella are gram-negative, facultatively intracellular bacterial pathogens that cause brucellosis in many animal species and humans. Although live, attenuated vaccines are available to protect several animal species from the disease, there is no safe and effective vaccine for human use. Here we report that a bacterium that is closely related to Brucella species, Ochrob...

2012
Ke Zheng Dong-Sheng Chen Yi-Quan Wu Xian-Jin Xu Hui Zhang Chuang-Fu Chen Huan-Chun Chen Zheng-Fei Liu

MicroRNA (miRNA) is small non-coding RNA with approximate 22 nt in length. Recent studies indicate that miRNAs play significant roles in pathogen-host interactions. Brucella organisms are Gram-negative facultative intracellular bacteria that cause Brucellosis. Brucella strains infect macrophages and establish chronic infection by altering host life activities including apoptosis and autophagy. ...

Journal: :Journal of immunology 2007
Richard Copin Patrick De Baetselier Yves Carlier Jean-Jacques Letesson Eric Muraille

IFN-gamma is a key cytokine controlling Brucella infection. One of its major function is the stimulation of Brucella-killing effector mechanisms, such as inducible NO synthase (iNOS)/NOS2 activity, in phagocytic cells. In this study, an attempt to identify the main cellular components of the immune response induced by Brucella melitensis in vivo is made. IFN-gamma and iNOS protein were analyzed...

2018
Dong Zhou Fei-Jie Zhi Mao-Zhen Qi Fu-Rong Bai Guangdong Zhang Jun-Mei Li Huan Liu Hua-Tao Chen Peng-Fei Lin Ke-Qiong Tang Wei Liu Ya-Ping Jin Ai-Hua Wang

Brucella is an intracellular bacterium that causes the zoonosis brucellosis worldwide. Alveolar macrophages (AM) constitute the main cell target of inhaled Brucella. Brucella thwarts immune surveillance and evokes endoplasmic reticulum (ER) stress to replicate in macrophages via virulence factors. The GntR regulators family was concentrated as an important virulence factor in controlling virule...

Journal: :Journal of infection in developing countries 2014
Gamal Wareth Falk Melzer Mandy C Elschner Heinrich Neubauer Uwe Roesler

INTRODUCTION Brucellosis in Egypt is an endemic disease among animals and humans. In endemic developing countries, dairy products produced from untreated milk are a potential threat to public health. The aim of this study was to detect brucellae in milk and milk products produced from apparently healthy animals to estimate the prevalence of contamination. METHODOLOGY Two hundred and fifteen u...

2016
Adrian M. Whatmore Mark S. Koylass Jakub Muchowski James Edwards-Smallbone Krishna K. Gopaul Lorraine L. Perrett

An extended multilocus sequence analysis (MLSA) scheme applicable to the Brucella, an expanding genus that includes zoonotic pathogens that severely impact animal and human health across large parts of the globe, was developed. The scheme, which extends a previously described nine locus scheme by examining sequences at 21 independent genetic loci in order to increase discriminatory power, was a...

2016
Y. Manat A.V. Shustov E. Evtehova S.Z. Eskendirova

Brucellosis is the lion's share of infectious disease of animals and it has a particular socio-economic importance for the Republic of Kazakhstan. Sixty percent of epizootic outbreaks of brucellosis identified in the Commonwealth of Independent States (CIS) originated from Kazakhstan in recent years. Definitive diagnosis of brucellosis remains a difficult task. Precisely for this reason, we eva...

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