PURPOSE Radiotherapy for breast cancer includes different techniques and methods. The purpose of this study is to compare dosimetric calculations using TG-43 dose formalism and Varian Acuros™ BV (GBBS) dose calculation algorithm for interstitial implant of breast using metal catheters in high-dose-rate (HDR) brachytherapy, using (192)Ir. MATERIAL AND METHODS Twenty patients who were considere...

After breast conserving surgery, early stage breast cancer patients are currently treated with a wide range of radiation techniques including whole breast irradiation (WBI), accelerated partial breast irradiation (APBI) using high-dose rate (HDR) brachytherapy, or 3D-conformal radiotherapy (3D-CRT). This study compares the mean heart's doses for a left breast irradiated with different breast te...

Breast conserving surgery (BCS) with following external beam radiation therapy (EBRT) of the conserved breast has become widely accepted in the last decades for the treatment of early invasive breast cancer. The standard technique of EBRT after BCS is to treat the whole breast up to a total dose of 42.5 to 50 Gy. An additional dose is given to treated volume as a boost to a portion of the breas...

BACKGROUND Radiotherapy during childhood increases long-term cancer risk, but the risk from radiation as a result of relatively higher dose diagnostic procedures remains less well known. This study, which evaluates breast cancer incidence in a cohort treated with "lower dose" chest radiotherapy over 50 years ago, can assist with estimating lifetime breast cancer risk in young children exposed t...

OBJECTIVES To assess potential infant exposure to bupropion and its active metabolites in breast milk such as would occur during treatment to prevent post-partum relapse to tobacco use, and to compare the concentrations of bupropion in urine and saliva with plasma and breast milk. DESIGN AND SETTING Cohort study, outpatient clinical research centre. SUBJECTS Ten healthy post-partum voluntee...

objectives: the aim of this study was to verify the treatment planning systems (tpss). the next aim was to validate imsure qa software for patient-specific qa in radiotherapy clinics.  material and methods: we used imsure qa software (standard imaging, v 3.5) for verification of 92 non-imrt plans (540 fields) in 10 radiotherapy clinics. to validate the imsure, dose measurement was performed in ...

BACKGROUND Much research has widely been conducted into thyroid hormones levels following radiotherapy for breast cancer. Consequently, in this study, we evaluated to relate the rate of thyroid hormones levels with the dose distribution among breast cancer patients. MATERIAL AND METHODS Thirty patients were treated with 4-field breast cancer radiotherapy. The dose volume histograms, the volum...

BED model (Biological Effective Dose) for Hyperfractionation TPO was optimized with Pareto-Multiobjective Genetic Algorithms (GA) software. Secondly, the NEffective (Effective Tumor Population Clonogens Number) optimization breast cancer clonogens parameters determination in (Treatment Planning Optimization) is carried out 3D Graphical and Interior Optimization methods. GA Results comprise imag...

BACKGROUND AND PURPOSE To present a novel helical TomoTherapy-based method for whole breast radiotherapy that has better dosimetry and also has acceptable low-dose regions for lungs, heart, and contralateral breast compared with tangential field-in-field IMRT (FIF-IMRT). MATERIAL AND METHODS Ten patients with left-side breast cancer were planned with low-dose-area-constrained helical TomoTher...

Background: We have validated the monitor unit calculations from a commercially available treatment planning system (TPS) for three intensity modulated radiotherapy (IMRT) planning techniques for tangential breast irradiation by using ionization chamber measurements. Materials and Methods: Treatment plans were generated for forty-two breast patients by a forward planned field in field ...