PURPOSE The empirical use of a chemotherapy regimen shows different results in individual breast cancer patient treatment. Recent studies showed the effectiveness of the adenosine triphosphate-based chemotherapy response assay (ATP-CRA). However, little is known about the correlation between chemosensitivity and breast cancer molecular subtypes. Therefore, we investigated whether the result of ...

the present research is a field study in order to investigate scale and ways of doing breast self examination (bse). 270 nurses employed by the medical sciences university’s hospitals related to the ministry of health, and medical education in city of tehran are selected and involved in research on the basis of simple random sampling. the data collection tool was a protrayed questionnaire which...

BACKGROUND Capecitabine has proven effective as a chemotherapy for metastatic breast cancer. Though several Phase II/III studies of capecitabine as neoadjuvant chemotherapy have been conducted, the results still remain inconsistent. Therefore, we performed a meta-analysis to obtain more precise understanding of the role of capecitabine in neoadjuvant chemotherapy for breast cancer patients. M...

Although neoadjuvant chemotherapy is a standard therapy for treating locally advanced breast cancer, it usually can’t achieve expected results owing to patients’ different chemotherapeutic sensitivity. At present, some certain progress have made in treating breast cancer by adjuvant chemotherapy combined with Traditional Chinese Medicine (TCM). Being effective for suppressing tumor growth, impr...

BACKGROUND Chemotherapy is an important component in the treatment paradigm for breast cancers. However, the resistance of cancer cells to chemotherapeutic agents frequently results in the subsequent recurrence and metastasis. Identification of molecular markers to predict treatment outcome is therefore warranted. The aim of the present study was to evaluate whether expression of circulating mi...

Background and objectives: Because of the importance of breast cancer as a first cause of morbidity and mortality among females, also the limitation of chemotherapy and based on literature of the use of herbal medicines against cancer, the current study was aimed to determine the efficacy of Berbers vulgaris fruit ethanol extract against MCF-7 breast cancer cell line. ...

BACKGROUND The addition of chemotherapy to endocrine therapy for luminal A breast cancer generally provides little benefit. However, the least benefit of chemotherapy in all patients with luminal A breast cancer is controversial. METHODS This was a retrospective study of 140 patients with luminal A breast cancer who underwent surgery at Tottori University Hospital between 2001 and 2010. Lumin...

Neoadjuvant chemotherapy increases survival of patients with locally advanced breast cancer. Very accurate predictors of chemotherapy response are essential for effective chemotherapeutic management due to the pronounced individual heterogeneity in breast cancer. Predictive molecular determinants for conventional chemotherapy are only emerging and still incorporate a high degree of predictive v...

PURPOSE Adjuvant chemotherapy for breast cancer can have adverse effects on cognition shortly after administration. Whether chemotherapy has any long-term effects on cognition is largely unknown, yet it becomes increasingly relevant because of the widespread use of chemotherapy for early-stage breast cancer and the improved survival. We investigated whether cyclophosphamide, methotrexate, and f...

Cancer therapies are associated with increased infertility risk due to accelerated reproductive aging. Oxidative stress (OS) is a potential mechanism behind ovarian toxicity by cyclophosphamide (CPM), the most ovotoxic anticancer drug. An important sensor of OS is SIRT1, a NAD+-dependent deacetylase which regulates cellular defence and cell fate. This study investigated whether the natural caro...