BACKGROUND/AIMS In patients with non-cardiac chest pain (NCCP), gastroesophageal reflux disease (GERD) is the commonest cause and ambulatory pH is of great value in identifying these patients. However, parameters in the context of predicting therapeutic response are still unknown. By extending the monitoring period, we could better evaluate the best evidence for GERD association. Our aims were ...

One of the disadvantages gel preparations is poor ability to penetrate skin. Herein we developed a sodium carboxymethylcellulose (NaCMC)-based containing microparticle doxycycline hyclate (DOX). Oleic acid (OA) was added into formulation specifically increase penetrability DOX microparticles. The objective this work determine effect varying concentration OA on physical characteristics, penetra...

Thirteen patients with metastatic breast carcinoma were given injec dons of 50—1593@ag of †̃311-monoclonal antibody (MAb) B6.2 immuno globulin G and F(ab')@for pharmacokinetic evaluation and radioimmu noimaging. Blood clearance of the †̃31I-MAb-B6.2 was biphasic. The mean half-times (t@, t@.,)for the immunoglobulin G were 33 ±1.7 and 20.9 ±11.0 h, respectively. The t@ for the F(ab'>@was 1...

Overexpression of the epithelial specific matrix metalloproteinase inatrilysin (MAT) has been correlated with enhanced tumorigenicity and tumor cell invasion using in vitro model systems. We have determined the effects of MAT expression on the development of mammary tumorigenesis using transgenic mice that express human MAT under the control of the mouse mammary tumor virus (MMTV)-long terminal...

We suggest and investigate a scheme for non-deterministic noiseless linear amplification of coherent states using successive photon addition, (â(†))(2), where â(†) is the photon creation operator. We compare it with a previous proposal using the photon addition-then-subtraction, ââ(†), where â is the photon annihilation operator, that works as an appropriate amplifier only for weak light fields...

Amitriptyline and Perphenazine in depressive ill ness: a controlled trial. I. Haider . . . . 195 Amnesic syndrome, the Grunthal-Störrmg case of.0. L. Zangwill .. .. .. .. i13 701 —¿ ————,—(C) .. .. .. .. 557 Amylobarbitone, cross-over study with Trimi 701 pramine. J. W. Hunter et a!. . . . . . . 667 —¿ sodium, controlled comparison with nitraze 383 pam (†̃Mogadon'). C. Davies an...

OBJECTIVE To evaluate post-operative sensitivity and secondary caries associated with posterior composite restoration. MATERIALS AND METHODS The study involved restoration of occlusal and proximo-occlusal caries on premolars and molars of 62 patients seen at the out-patient clinic of the restorative department of the Lagos University Teaching Hospital. The restorations were completed with a m...

The proliferating cell nuclear antigen (PCNA) is a nuclear protein of about 29000Mr, which was independently discovered by Miyachi et al. (1978) as PCNA and by Bravo and Celis (1980) as cyclin. More recently it has been identified as the co-factor of DNA polymerase delta (Prelich et al. 1987a; Bravo et al. 1987), a protein that had been previously isolated by Tan et al. (1986). Both DNA polymer...

To determine the type of mutation induced by 8-hydroxyguanine in a mammalian system, we examined the mutations induced by a synthetic i -I la-ruv protooncogene containing 8-hydroxyguanine in the second po sition of codon 12 (GGC) in NIH3T3 cells. Transaction of this gene significantly increased the number of transformed foci. The c-Ha-r<w gene present in these foci was analyzed by the polymeras...