Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in humans, accounting for 12-15% of all brain tumors. The first therapeutic approache in this tumor is to perform maximal surgical resection with preserving neurologic functions. Currently,adjuvant radiotherapy (combined with chemotherapy or alone) following surgery is the standard treatment with proven positive...

OBJECTIVE Extracranial bone metastases from astrocytoma are rare and frequently detected as part of multiorgan metastases. It is extremely rare for astrocytoma to have extracranial bone metastases alone. The importance of whole-body fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) imaging in evaluating extracranial metastasis (ECMs) has not been described effecti...

BACKGROUND AND PURPOSE [(11)C]Methionine (MET) PET imaging is a sensitive technique for visualizing primary brain tumors and recurrence/progression after therapy. The aim of this study was to evaluate the relationship between the uptake of MET and histopathologic grading and to investigate the prognostic value of the tracer, in both settings. METHODS Cerebral uptake of MET was determined in 5...

Abstract Glioblastoma (GBM), the most common primary brain tumor in adults, has a dismal prognosis and nearly 100% recurrence rate. With median age of diagnosis 64, associated immune dysfunction needs to be accounted for during treatment. Cannonically, immunotherapies target checkpoint signaling pathways order create T-cell populations that are resistant exhaustion. Our lab demonstrated exhaust...

CONTEXT In patients with brain metastases, it is unclear whether adding up-front whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has beneficial effects on mortality or neurologic function compared with SRS alone. OBJECTIVE To determine if WBRT combined with SRS results in improvements in survival, brain tumor control, functional preservation rate, and frequency of neur...

Recent advances in medical image analysis have been made to improve our understanding of how disease develops, behaves, and responds treatment. Magnetic resonance imaging (MRI) positron emission tomography (PET) advanced strategies provide structural functional phenotypic biomarkers that correlate with key processes. Through radiomics radiogenomics, ML-medical has opened up new perspectives hig...

INTRODUCTION Medulloblastoma, the most frequent brain tumor in childhood, also occurs with a wide range of characteristics in adult patients. Late relapse is common in adult medulloblastoma, and the overall survival of relapsed patients usually ranges from 12 to 15 months. Treatment at recurrence is still debated and after reoperation includes stereotactic or normofractionated radiotherapy, and...

Purpose: Non–small cell lung cancer (NSCLC) includes a spectrum of radiosensitive and radioresistant tumors. However, little is known about the molecular determinants of cellular radiation responses. We examined clinical outcomes after gamma knife radiotherapy for NSCLC intracranial metastases to evaluate the use of this model for determining radiosensitive tumor genotypes. Experimental Design:...

Brain parenchyma schwannoma is a rare intracranial tumor, and especially rare in cerebellar hemisphere. In this report, a case of cerebellar schwannoma in a 52-year-old woman, was studied by computed tomography (CT), magnetic resonance image (MRI) and PET-CT. This tumor was totally removed by surgery. The histological diagnosis of schwannoma was confirmed by histological, HE and immunohistologi...

Abstract We are developing ZIKV as a therapy for GBM. previously demonstrated specifically kills GBM stem cells. Using GL261 and CT2A mouse models, induces CD8+ T-cell mediated anti-tumor response leads to 65% 40% long term survivors, respectively (0%-untreated controls). treatment significantly increases the number of myeloid cells in tumor microenvironment (with about 10,000 infiltrating macr...