Rationale: Diffuse intrinsic pontine glioma (DIPG) is a lethal brain tumor and leading cause of tumor–related death in children. Over the past few decades, clinical trials have shown no improvement outcome. Most DIPGs occur pediatric population. Adult brainstem gliomas are rare, constitute less than 2% adult gliomas, show slight male predominance. The case this 25-year-old female presented to d...

the molecular basis of metastatic potential of human breast carcinoma cells can be useful information to determine the practical implications in the diagnosis, determining prognosis and treatment of breast cancer. the aim of this study was to identify predictors of aggressive biological behavior and metastatic potential in breast carcinoma among a number of intrinsic biomarkers of tumor cells. ...

BACKGROUND AND PURPOSE Diffusion-weighted images (DWIs) have been used to study various diseases, particularly since echo-planar techniques shorten examination time. Our hypothesis was that DWIs and tumor apparent diffusion coefficients (ADCs) could provide additional useful information in the diagnosis of patients with brain tumors. METHODS Using a 1.5-T MR unit, we examined 56 patients with...

TWIST, a basic helix-loop-helix (bHLH) transcription factor that regulates mesodermal development, has been shown to promote tumor cell metastasis and to enhance survival in response to cytotoxic stress. Our analysis of rat C6 glioma cell-derived cDNA revealed TWIST expression, suggesting that the gene may play a role in the genesis and physiology of primary brain tumors. To further delineate a...

The objective of this study is to investigate the use of pattern classification methods for distinguishing different types of brain tumors, such as primary gliomas from metastases, and also for grading of gliomas. The availability of an automated computer analysis tool that is more objective than human readers can potentially lead to more reliable and reproducible brain tumor diagnostic procedu...

PURPOSE Plasmalemmal vesicle associated protein-1 (PV-1) is up-regulated in the endothelium of human glioblastoma. We sought to further characterize the expression pattern of PV-1 in human brain tumors and interrogate its role in brain tumor angiogenesis. EXPERIMENTAL DESIGN Quantitative reverse transcription-PCR and in situ hybridization were used to measure PV-1 expression in a panel of 46 ...

background & aim: glioblastoma multiforme (gbm), the highest grade glioma (grade iv), is the most malignant form of astrocytoma in adults. this study aimed at evaluating the relationship between demographic, clinical and medical factors with gbm outcome. methods & materials/patients: through a cross-sectional design, 58 patients with newly diagnosed gbm were studied from 1999 to 2015 in guilan ...

background and objective: male breast carcinoma (mbc) is an unusual form of neoplasia, representing 0.7 to 1 percent of all breast cancer cases. usually, the carcinoma affects patients after the sixth decade. the aim of this study was to evaluate the status of estrogen and progesterone receptors (er and pr) and prognostic factors (p53 and her-2/neu) in a series of male patients with breast canc...

Primary brain tumors are presently classified based on imaging and histopathological techniques, which remains unsatisfaying. We profiled here by quantitative real time PCR (qRT-PCR) the transcripts of eighteen histone deacetylases (HDACs) and a subset of transcriptional co-factors in non-tumoral brain samples from 15 patients operated for epilepsia and in brain tumor samples from 50 patients d...

The up-regulation of cyclooxygenase 2 (COX-2) expression is a frequent occurrence in a variety of different tumors. In this study, COX-2 protein expression was investigated in 50 glioma and 3 normal brain specimens by immunohistochemistry. Expression of COX-2 protein was observed in all normal brain and glioma specimens by immunohistochemistry, regardless of histological grade. The immunoreacti...