نتایج جستجو برای: brain iron accumulation
تعداد نتایج: 749017 فیلتر نتایج به سال:
Aceruloplasminemia is a monogenic disease caused by mutations in the ceruloplasmin gene that result in loss of protein ferroxidase activity. Ceruloplasmin plays a role in iron homeostasis, and its activity impairment leads to iron accumulation in liver, pancreas, and brain. Iron deposition promotes diabetes, retinal degeneration, and progressive neurodegeneration. Current therapies mainly based...
Oxidative stress plays an important role in neuronal injuries caused by cerebral ischemia. It is well established that free iron increases significantly during ischemia and is responsible for oxidative damage in the brain. However, the mechanism of this ischemia-induced increase in iron is not completely understood. In this report, the middle cerebral artery occlusion (MCAO) rat model was perfo...
A prominent decreased signal intensity can be seen in many of the heavily myelinated, compact fiber pathways of the brain on T2-weighted spin-echo MR images (TR = 2500 msec, TE = 80 msec). These areas include the anterior commissure, internal capsule, optic tract and radiations, fornix, mammillothalamic tract, superior frontooccipital fasciculus, cingulum, corpus callosum, uncinate fasciculus, ...
OBJECTIVES From previous data in animal models of cerebral ischemia, lipocalin-2 (LCN2), a protein related to neutrophil function and cellular iron homeostasis, is supposed to have a value as a biomarker in ischemic stroke patients. Therefore, we examined LCN2 expression in the ischemic brain in an animal model and measured plasma levels of LCN2 in ischemic stroke patients. METHODS In the mou...
AIM Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular phenomenon recently described in multiple sclerosis (MS) that is characterized by stenoses affecting the main extracranial venous outflow pathways and by a high rate of cerebral venous reflux that may lead to increased iron deposition in the brain. Aim of this study was to investigate the relationship between CCSVI and iron de...
Maternal iron deficiency (ID) and environmental lead (Pb) exposure are co-occurring insults that both affect the neurodevelopment of offspring. Few studies have investigated how ID affects brain-region-specific Pb accumulations using human-relevant concentrations. Furthermore, these exposures impact blood brain Fe levels remains unclear. Importantly, we also wanted to determine whether use as a...
The abnormal accumulation of iron in the brain has previously been proposed to be responsible for the neurodegenerative diseases through the oxidative damage to neuronal cells. Therefore, it seems practically meaningful to search for novel active substances protecting neurons against the iron-induced oxidative neurotoxicity in vitro. For this purpose, the aqueous extract was prepared from a spo...
Aberrant iron deposition in the brain is associated with neurodegenerative disorders including Multiple Sclerosis, Alzheimer's disease and Parkinson's disease. To study the collective response to iron loading, we have used hippocampal organotypic slices as a platform to develop a novel ex vivo model of iron accumulation. We demonstrated differential uptake and toxicity of iron after 12 h exposu...
PURPOSE: To provide further quantitative studies concerning the relationship with age between regional brain iron and T2 shortening. METHODS: a) Quantitative T2 calculations of eight anatomic regions (red nucleus, substantia nigra, dentate nucleus, corpus callosum, caudate, putamen, temporal lobe white matter, and frontal lobe white matter) from T2-weighted spin-echo images were performed in 60...
pantothenate kinase- associated neurodegeneration (pkan) syndrome is a rare autosomal recessive disorder characterized by progressive extrapyramidal dysfunction and iron accumulation in the brain and axonal spheroids in the central nervous system. it has been shown that the disorder is caused by mutations in pank2 gene which codes for a mitochondrial enzyme participating in coenzyme a biosynthe...
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