PURPOSEImage-guided adaptive brachytherapy (IGABT) recently has shown excellent clinical outcomes with superior local control and less toxicity. For IGABT, T2W (T2-weighted) MRI is the gold standard. However, studies have that target delineation same results in uncertainties, poor interobserver variabilities, low conformity indices for high-risk volume contours. In this study, we investigate ro...

Activation of the A(2A) adenosine receptor (A(2A)R) has been shown to be cardioprotective. We hypothesized that A(2A)R overexpression could protect the heart from adriamycin-induced cardiomyopathy. Transgenic (TG) mice overexpressing the A(2A)R and wild-type mice (WT) were injected with adriamycin (5 mg.kg(-1).wk(-1) ip, 4 wk). All WT mice survived adriamycin treatment while A(2A)R TG mice suff...

PURPOSE To evaluate the patterns of regression of iris melanoma after treatment with palladium-103 (103Pd) plaque brachytherapy. DESIGN Retrospective, nonrandomized, interventional case series. PARTICIPANTS Fifty patients with primary malignant melanoma of the iris. METHODS Palladium-103 plaque brachytherapy. MAIN OUTCOME MEASURES Changes in tumor size, pigmentation, and vascularity; in...

Brachytherapy reduces the post radiation sequalae as dose required is lower than external beam therapy (EBRT) and limits area of exposure. This case report outlines two different patients managed by fabrication carrier prosthesis for duration brachytherapy.

OBJECTIVE Although many studies have reported that elevated serum triglycerides to high-density lipoprotein cholesterol (TG-HDL) ratios constitute a risk for insulin resistance and increased arterial stiffness, no study has clarified as yet the association, in terms of the TG-HDL ratio, between diabetes and increased arterial stiffness evaluated by means of carotid intima-media thickness (CIMT)...

We studied Ca(2+) dependence of tension and actomyosin ATPase rate in detergent extracted fiber bundles isolated from transgenic mice (TG), in which cardiac troponin I (cTnI) serines 43 and 45 were mutated to alanines (cTnI S43A/S45A). Basal phosphorylation levels of cTnI were lower in TG than in wild-type (WT) mice, but phosphorylation of cardiac troponin T was increased. Compared with WT, TG ...

PURPOSE Historically, treatment of malignant surface lesions has been achieved with linear accelerator based electron beams or superficial x-ray beams. Recent developments in the field of brachytherapy now allow for the treatment of surface lesions with specialized conical applicators placed directly on the lesion. Applicators are available for use with high dose rate (HDR)(192)Ir sources, as w...

Background: The Patterson-Parker table was created in 1934 to determine mg-hr required to deliver the prescribed dose to the treatment area. These tables were created using the dosimetric data for 226Ra that was determined in air and were utilized for dose calculations around implants with Ra-equivalent radionuclides such as 137Cs and 192Ir. Therefore, the differences of the tissue attenuation ...

introduction in this study, we aimed to calculate dose enhancement factor (def) for gold (au) and iron (fe) nanoparticles (nps) in brachytherapy and teletherapy, using monte carlo (mc) method. materials and methods in this study, a new algorithm was introduced to calculate dose enhancement by aunps and fenps for iridium-192 (ir-192) brachytherapy and cobalt-60 (co-60) teletherapy sources, using...

INTRODUCTION MRI-guided prostate brachytherapy is feasibile and is efficacious for early-stage prostate cancer. The current standard of practice is to attempt to reduce radiation doses to the bilateral neurovascular bundles (NVBs) adjacent to the prostate gland in order to prevent possible erectile dysfunction (1-4). It has been demonstrated MRI can visualize the NVBs, and hence should be usefu...